The Efficacy and Safety of Cilomilast in COPD

  title={The Efficacy and Safety of Cilomilast in COPD},
  author={Larson Professor of Medicine Stephen Rennard and Katharine Knobil and Klaus Friedrich Rabe and Andrea Morris and Neil E. Schachter and Nicholas W Locantore and W Canonica and Yuanjue Zhu and Frank Barnhart},
The aim of this review is to present the clinical data on the efficacy and safety of cilomilast in patients with chronic obstructive pulmonary disease (COPD). Over 6000 COPD patients received cilomilast during an extensive clinical development programme performed by GlaxoSmithKline (GSK). Five phase III randomized, double-blind, placebo-controlled, parallel-group pivotal studies were conducted in poorly reversible patients (<15% or <200 mL improvement over baseline in forced expiratory volume… CONTINUE READING


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