The Effects of the Tramadol Metabolite O-Desmethyl Tramadol on Muscarinic Receptor-Induced Responses in Xenopus Oocytes Expressing Cloned M1 or M3 Receptors

@article{Nakamura2005TheEO,
  title={The Effects of the Tramadol Metabolite O-Desmethyl Tramadol on Muscarinic Receptor-Induced Responses in Xenopus Oocytes Expressing Cloned M1 or M3 Receptors},
  author={Motohiro Nakamura and Kouichiro Minami and Yasuhito Uezono and Takafumi Horishita and Junichi Ogata and Munehiro Shiraishi and Takashi Okamoto and Tadanori Terada and Takeyoshi Sata},
  journal={Anesthesia \& Analgesia},
  year={2005},
  volume={101},
  pages={180-186}
}
O-desmethyl tramadol is one of the main metabolites of tramadol. It has been widely used clinically and has analgesic activity. Muscarinic receptors are involved in neuronal functions in the brain and autonomic nervous system, and much attention has been paid to these receptors as targets for analgesic drugs in the central nervous system. We have reported that tramadol inhibits the function of type-1 muscarinic (M1) receptors and type-3 muscarinic (M3) receptors, suggesting that muscarinic… 

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