The Effects of the Potassium Channel Opener Minoxidil on Renal Electrolytes Transport in the Loop of Henle

  title={The Effects of the Potassium Channel Opener Minoxidil on Renal Electrolytes Transport in the Loop of Henle},
  author={Tong Wang},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={833 - 840}
  • Tong Wang
  • Published 2003
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • ATP-sensitive potassium channels (KATP) in the thick ascending limb of the loop of Henle play an important role in apical K+ recycling, a mechanism essential for maintaining the activity of the Na/2Cl/K-cotransporter. We have previously demonstrated that inhibition of KATP decreases Na+ and K+ absorption in the loop of Henle and induces diuretic and natriuretic effects. In the present study, we used renal clearance and in vivo microperfusion techniques to evaluate the effects of the KATP opener… CONTINUE READING
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