The Effects of radiation on the safety and protective efficacy of an attenuated Plasmodium yoelii sporozoite malaria vaccine.

@article{Chattopadhyay2009TheEO,
  title={The Effects of radiation on the safety and protective efficacy of an attenuated Plasmodium yoelii sporozoite malaria vaccine.},
  author={R. N. Chattopadhyay and Solomon Conteh and Minglin Li and Eric R. James and Judith E. Epstein and Stephen L Hoffman},
  journal={Vaccine},
  year={2009},
  volume={27 27},
  pages={3675-80}
}
We are developing a radiation attenuated Plasmodium falciparum sporozoite (PfSPZ) malaria vaccine. An important step was to determine the minimum dose of irradiation required to adequately attenuate each sporozoite. This was studied in the Plasmodium yoelii rodent model system. Exposure to 100 Gy completely attenuated P. yoelii sporozoites (PySPZ). Next we demonstrated that immunization of mice intravenously with 3 doses of 750 PySPZ that had received 200 Gy, double the radiation dose required… CONTINUE READING

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