The Effects of a Novel Series of Selective Inhibitors of Arachidonate 5‐Lipoxygenase on Anaphylactic and Inflammatory Responses

@article{Bhattacherjee1988TheEO,
  title={The Effects of a Novel Series of Selective Inhibitors of Arachidonate 5‐Lipoxygenase on Anaphylactic and Inflammatory Responses},
  author={P. Bhattacherjee and N. K. BOUGHTON‐SMITH and R. Follenfant and L. Garland and G. Higgs and H. Hodson and P. J. Islip and W. Jackson and S. Moncada and A. Payne and R. Randall and C. Reynolds and J. Salmon and J. E. Tateson and B. Whittle},
  journal={Annals of the New York Academy of Sciences},
  year={1988},
  volume={524}
}
  • P. Bhattacherjee, N. K. BOUGHTON‐SMITH, +12 authors B. Whittle
  • Published 1988
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • In conclusion, we have described a novel series of acetohydroxamic acids that are potent and selective inhibitors of arachidonate 5-lipoxygenase in vitro and in vivo. In addition, we have shown that these compounds attenuate "leukotriene-dependent" anaphylactic bronchospasm, the accumulation of inflammatory leukocytes, and the development of fever in experimental models. It now remains to be determined if these compounds have any therapeutic value in man. 
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