The Effects of a Bottleneck on Inbreeding Depression and the Genetic Load

@article{Kirkpatrick2000TheEO,
  title={The Effects of a Bottleneck on Inbreeding Depression and the Genetic Load},
  author={M. Kirkpatrick and P. Jarne},
  journal={The American Naturalist},
  year={2000},
  volume={155},
  pages={154 - 167}
}
We study the effects of a population bottleneck on the inbreeding depression and genetic load caused by deleterious mutations in an outcrossing population. The calculations assume that loci have multiplicative fitness effects and that linkage disequilibrium is negligible. Inbreeding depression decreases immediately after a sudden reduction of population size, but the drop is at most only several percentage points, even for severe bottlenecks. Highly recessive mutations experience a purging… Expand
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