The Effects of Zafirlukast on Capsular Contracture: Preliminary Report

@article{Scuderi2006TheEO,
  title={The Effects of Zafirlukast on Capsular Contracture: Preliminary Report},
  author={Nicolo' Scuderi and Marco Mazzocchi and Paolo Fioramonti and Giovanni Bistoni},
  journal={Aesthetic Plastic Surgery},
  year={2006},
  volume={30},
  pages={513-520}
}
Capsular contracture after breast augmentation is a distressing, troublesome event both for the patient and the surgeon. Fibrosis transforms the prosthesis into a hardened sphere, turning the initially satisfactory cosmetic result into a deformed mass. Treatment for capsular contracture can be either surgical, consisting of capsulotomy or capsulectomy with implant replacement, or pharmacologic, consisting of intracapsular instillation of steroids and antibiotics. The success rates for both… 
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Capsular contracture: what is it? What causes it? How can it be prevented and managed?
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  • 2009
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The basis for capsular contracture is reviewed, the methods to prevent it and treat it when it occurs are defined and surgical total capsulectomy with site change when indicated and replacement with a new implant is performed.
Prophylactic Leukotriene Inhibitor Therapy for the Reduction of Capsular Contracture in Primary Silicone Breast Augmentation: Experience with over 1100 Cases
  • S. Bresnick
  • Medicine
    Plastic and Reconstructive Surgery
  • 2017
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It is suggested that Accolate therapy, with monitoring and consent, reduces the incidence of capsular contracture following primary smooth silicone gel breast augmentation, with or without postoperative leukotriene inhibitor therapy.
Suppressive Effect of Leukotriene Antagonists on Capsular Contracture in Patients Who Underwent Breast Surgery with Prosthesis: A Meta-Analysis
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It is demonstrated that leukotriene antagonists (montelukast and zafirlukast) have significant effects in treating and preventing capsular contracture.
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