The Effects of Vasopressin on Systemic Hemodynamics in Catecholamine-Resistant Septic and Postcardiotomy Shock: A Retrospective Analysis

@article{Dnser2001TheEO,
  title={The Effects of Vasopressin on Systemic Hemodynamics in Catecholamine-Resistant Septic and Postcardiotomy Shock: A Retrospective Analysis},
  author={Martin W D{\"u}nser and Andreas J. Mayr and Hanno Ulmer and Nicole Ritsch and Hans Knotzer and Werner Pajk and G{\"u}nther Luckner and Norbert J Mutz and Walter R. Hasibeder},
  journal={Anesthesia \& Analgesia},
  year={2001},
  volume={93},
  pages={7–13}
}
We retrospectively investigated the effects of continuous arginine vasopressin (AVP) infusion on systemic hemodynamics, acid/base status, and laboratory variables in patients (mean age [mean ± sd]= 66.3 ± 10.1 yr) with catecholamine-resistant septic (n = 35) or postcardiotomy shock (n = 25). Hemodynamic and acid/base data were obtained before; 30 min after; and 1, 4, 12, 24, 48, and 72 h after the start of AVP infusion. Laboratory examinations were recorded before and 24, 48, and 72 h after the… Expand

Paper Mentions

Interventional Clinical Trial
This is an investigator initiated, prospective, single-center, double-blinded, randomized, placebo-controlled trial of post-operative low dose vasopressin infusions as an early… Expand
ConditionsCirculatory Perfusion Disorder, Congenital Heart Disease, Single-ventricle
InterventionDrug
Arginine vasopressin in 316 patients with advanced vasodilatory shock*
TLDR
Supplementary AVP infusion improved cardiocirculatory function in advanced vasodilatory shock, but an increase in liver enzymes and bilirubin, and a decrease in platelet count occurred during AVP therapy, particularly during simultaneous hemofiltration. Expand
The effect of vasopressin on gastric perfusion in catecholamine-dependent patients in septic shock.
TLDR
In norepinephrine-dependent patients in septic shock, continuous infusion of low-dose vasopressin results in a significant increase of the P(g-a)CO(2) gap compatible with GI hypoperfusion. Expand
The Effect of Vasopressin on Gastric Perfusion in Catecholamine-Dependent Patients in Septic Shock.
TLDR
In norepinephrine-dependent patients in septic shock, continuous infusion of low-dose vasopressin results in a significant increase of the P[g-a]CO2 gap compatible with gastrointestinal hypoperfusion. Expand
The Therapeutic Role of Vasopressin on Improving Lactate Clearance During and After Vasogenic Shock: Microcirculation, Is It The Black Box?
TLDR
Although lactate levels did not significantly differ between treatment groups, lactate clearance at 24 hours was significantly higher in vasopressin group, which may be the effect of vasopressing effect on microcirculation and tissue hypoperfusion or its catecholamine sparing effect. Expand
Vasopressin or norepinephrine in early hyperdynamic septic shock: a randomized clinical trial
TLDR
In early hyperdynamic septic shock, the administration of high-dose AVP as a single agent fails to increase mean arterial pressure in the first hour but maintains it above 70 mmHg in two-thirds of patients at 48 h, and the PrCO2 – PaCO2 difference remained stable throughout the study. Expand
Effects of Continuous Vasopressin Infusion in Patients with Septic Shock
TLDR
Vasopressin infusion was effective in increasing MAP and reducing heart rate while decreasing the dopamine dosage in patients with septic shock, and Comparative studies with catecholamine vasopressors are needed to define the optimal role of vasopressing in septicshock therapy. Expand
Intravenous Arginine Vasopressin Infusion in Refractory Vasodilatory Shock: A Clinical Study
TLDR
Concurrent addition of vasopressin at an appropriate stage help improve Mean arterial blood pressure significantly with decreased dependence on high dose catecholamines without any significant adverse effects. Expand
Arginine Vasopressin in Advanced Vasodilatory Shock: A Prospective, Randomized, Controlled Study
TLDR
The combined infusion of AVP and NE proved to be superior to infusion of NE alone in the treatment of cardiocirculatory failure in catecholamine-resistant vasodilatory shock. Expand
High-dose vasopressin is not superior to norepinephrine in septic shock*
TLDR
It does not appear beneficial to directly replace norepinephrine with vasopressin in septic shock patients, and an increased gastric Pco2 gap suggests that the gut blood flow could have been redistributed to the disadvantage of the mucosa. Expand
Comparing two different arginine vasopressin doses in advanced vasodilatory shock: a randomized, controlled, open-label trial
TLDR
A supplementary AVP infusion of 0.067 IU/min restores cardiovascular function in patients with advanced vasodilatory shock more effectively than AVP at 0.033  IU/min. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 32 REFERENCES
Arginine vasopressin in the treatment of 50 patients with postcardiotomy vasodilatory shock.
TLDR
Vasopressin at low doses to be a safe and an effective vasopressor in 50 patients with postcardiotomy vasodilatory shock is demonstrated. Expand
Vasopressin deficiency contributes to the vasodilation of septic shock.
TLDR
Vasopressin plasma levels are inappropriately low in vasodilatory shock, most likely because of impaired baroreflex-mediated secretion. Expand
Reversal by vasopressin of intractable hypotension in the late phase of hemorrhagic shock.
TLDR
Vasopressin is a uniquely effective pressor in the irreversible phase of hemorrhagic shock unresponsive to volume replacement and catecholamine vasopressors and may contribute to the pathogenesis of this condition. Expand
Lysine vasopressin in the treatment of refractory hemodialysis-induced hypotension.
TLDR
The utility of LV in the treatment of refractory hemodialysis-induced hypotension is demonstrated, and baseline epinephrine, norepinephrine, and antidiuretic hormone levels were elevated above normal levels and fell with hypotension despite the use of LV. Expand
Effects of vasopressin on the circulation and its baroreflex control in healthy men.
TLDR
The maximal vasoconstrictor response in the forearm attained during lower body negative pressure was not influenced by AVP, but the reflex vasodilator response to the sudden release of lower bodynegative pressure was significantly augmented, vascular resistance falling to 23 +/- 4 U before and 13 +/- 2 U during AVP. Expand
A prospective randomized trial of arginine vasopressin in the treatment of vasodilatory shock after left ventricular assist device placement.
TLDR
Vasopressin is an effective pressor in vasodilatory shock after cardiopulmonary bypass in patients undergoing placement of a left ventricular assist device, and all subjects responded to vasoppressin administration. Expand
Vasopressin as an alternative to norepinephrine in the treatment of milrinone‐induced hypotension
TLDR
Vasopressin at very low doses appears to be an effective vasopressor for milrinone‐induced hypotension. Expand
Hemodynamic effects of lysine-vasopressin in orthostatic hypotension.
  • M. Kochar
  • Medicine
  • American journal of kidney diseases : the official journal of the National Kidney Foundation
  • 1985
TLDR
Lypressin did not significantly alter the effect of tilt on heart rate, stroke volume, and cardiac output but increased the blood pressure and total peripheral resistance and should be tested for treating chronic postural hypotension. Expand
The Role of Vasopressin in the Treatment of Vasodilation in Shock States
TLDR
Vasopressin may be a reasonable alternative for patients in vasodilatory shock, however, larger-scale controlled clinical trials are warranted before its routine use can be recommended. Expand
The hemodynamic effects of anesthetic induction in vascular surgical patients chronically treated with angiotensin II receptor antagonists.
TLDR
Hypotension refractory to repeated ephedrine or phenylephrine administration occurred significantly more in the ARA group compared with the BB/CB group or the ACEI group, but it was treated successfully by using a vasopressin system agonist. Expand
...
1
2
3
4
...