The Effects of Sildenafil Citrate on the Liver and Kidneys of Adult Wistar Rats ( Rattus norvegicus ) – A Histological Study

@inproceedings{Eweka2012TheEO,
  title={The Effects of Sildenafil Citrate on the Liver and Kidneys of Adult Wistar Rats ( Rattus norvegicus ) – A Histological Study},
  author={Andrew Osayame Eweka and Abieyuwa Eweka},
  year={2012}
}
Sildenafil citrate is widely used as an effective and safe oral treatment for erectile dysfunction of various etiologies (Goldstein et al., 1998; Cheitlin et al., 1999; Benchekroun et al., 2003). It is a potent and selective inhibitor of phosphodiesterase type 5 enzymes that acts to break down cyclic guanosine monophosphate (cGMP) (Boolell et al., 1996). The medication amplifies the effect of sexual stimulation by retarding the degradation of this enzyme. Sildenafil has been found effective in… CONTINUE READING