The Effects of Restraint Stress on the Neuropathogenesis of Theiler's Virus Infection: I. Acute Disease

@article{Campbell2001TheEO,
  title={The Effects of Restraint Stress on the Neuropathogenesis of Theiler's Virus Infection: I. Acute Disease},
  author={Trudy Campbell and Mary W. Meagher and Amy N. Sieve and Brian S. Scott and C. Jane Welsh},
  journal={Brain, Behavior, and Immunity},
  year={2001},
  volume={15},
  pages={235-254}
}
Restraint stress was found to have a profound effect on the acute phase of Theiler's virus infection. Increased mortality rates were observed in restrained CBA mice infected with the BeAn strain of Theiler's virus. In addition, restrained mice developed higher CNS viral titers than infected/nonrestrained mice. Thymic atrophy was observed in both infected and uninfected restrained mice. Decreased microgliosis, perivascular cuffing, and astrocytosis were observed in restrained mice compared to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations