The Effects of Novel, Selective 5-Hydroxytryptamine (5-HT)4 Receptor Ligands in Rat Spatial Navigation

@article{Fontana1997TheEO,
  title={The Effects of Novel, Selective 5-Hydroxytryptamine (5-HT)4 Receptor Ligands in Rat Spatial Navigation},
  author={David J. Fontana and S. E. Daniels and Erik H. F. Wong and Robin Douglas Clark and R. M. Eglen},
  journal={Neuropharmacology},
  year={1997},
  volume={36},
  pages={689-696}
}
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107 Citations
Highly Influential Citations
6
Background Citations
33
Methods Citations
5
Results Citations
2

107 Citations

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The data suggest that 5-HT(4) receptors may regulate behavioral processes dependent on mesolimbic DA pathways and may provide a novel target for the development of medications useful in the treatment of both drug dependence and psychiatric disorders.

Antagonism of 5-Hydroxytryptamine4 Receptors Attenuates Hyperactivity Induced by Cocaine: Putative Role for 5-Hydroxytryptamine4 Receptors in the Nucleus Accumbens Shell

The data suggest that 5-HT4 receptors may regulate behavioral processes dependent on mesolimbic DA pathways and may provide a novel target for the development of medications useful in the treatment of both drug dependence and psychiatric disorders.

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The ability of 5-HT4 receptor agonists to reverse spontaneous working memory deficits is demonstrated and the therapeutic potential of such ligands in the treatment of cognitive alterations that associate short-term working memory disorders and cholinergic hypofunction is confirmed.

SL65.0155, A Novel 5-Hydroxytryptamine4 Receptor Partial Agonist with Potent Cognition-Enhancing Properties

Its broad range of activity in cognitive tests and synergism with cholinesterase inhibitors suggest that SL65.0155 represents a promising new agent for the treatment of dementia.

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Findings show for the first time that the 5-HT4 receptor agonists prucalopride and PRX-03140 can increase cortical ACh and histamine levels, augment donepezil-induced ACh increases, and increase stimulated-hippocampal θ power, all neuropharmacological parameters consistent with potential positive effects on cognitive processes.

Modulation of memory processes and cellular excitability in the dentate gyrus of freely moving rats by a 5-HT4 receptors partial agonist, and an antagonist

5-HT4 receptors do not mediate the antidepressant-like behavioral effects of fluoxetine in a modified forced swim test.

Cognitive effects of SL65.0155, a serotonin 5-HT4 receptor partial agonist, in animal models of amnesia

Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines.

...

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