The Effects of Novel, Selective 5-Hydroxytryptamine (5-HT)4 Receptor Ligands in Rat Spatial Navigation

@article{Fontana1997TheEO,
  title={The Effects of Novel, Selective 5-Hydroxytryptamine (5-HT)4 Receptor Ligands in Rat Spatial Navigation},
  author={David J. Fontana and S. E. Daniels and Erik H. F. Wong and Robin Douglas Clark and R. M. Eglen},
  journal={Neuropharmacology},
  year={1997},
  volume={36},
  pages={689-696}
}

Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell.

The data suggest that 5-HT(4) receptors may regulate behavioral processes dependent on mesolimbic DA pathways and may provide a novel target for the development of medications useful in the treatment of both drug dependence and psychiatric disorders.

Antagonism of 5-Hydroxytryptamine4 Receptors Attenuates Hyperactivity Induced by Cocaine: Putative Role for 5-Hydroxytryptamine4 Receptors in the Nucleus Accumbens Shell

The data suggest that 5-HT4 receptors may regulate behavioral processes dependent on mesolimbic DA pathways and may provide a novel target for the development of medications useful in the treatment of both drug dependence and psychiatric disorders.

BIMU 1 and RS 67333, two 5-HT4 receptor agonists, modulate spontaneous alternation deficits induced by scopolamine in the mouse

The ability of 5-HT4 receptor agonists to reverse spontaneous working memory deficits is demonstrated and the therapeutic potential of such ligands in the treatment of cognitive alterations that associate short-term working memory disorders and cholinergic hypofunction is confirmed.

The 5-Hydroxytryptamine4 Receptor Agonists Prucalopride and PRX-03140 Increase Acetylcholine and Histamine Levels in the Rat Prefrontal Cortex and the Power of Stimulated Hippocampal θ Oscillations

Findings show for the first time that the 5-HT4 receptor agonists prucalopride and PRX-03140 can increase cortical ACh and histamine levels, augment donepezil-induced ACh increases, and increase stimulated-hippocampal θ power, all neuropharmacological parameters consistent with potential positive effects on cognitive processes.
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References

SHOWING 1-10 OF 26 REFERENCES

Ability of 5‐HT4 receptor ligands to modulate rat striatal dopamine release in vitro and in vivo

Evidence is provided that the 5‐HT4 receptor facilitates rat striatal dopamine release in vitro and in vivo and both the Na+ channel blocker and the non‐selective protein kinase A inhibitor completely prevented the stimulation of dopamine release induced by renzapride (10 μm).

[3H]-GR113808 labels 5-HT4 receptors in the human and guinea-pig brain.

In vitro ligand binding autoradiography was used to investigate the distribution of [3H]-GR113808 recognition sites on human brain sections and found the highest density was observed in the striato-nigral system, similar to that found in the guinea-pig brain.

Central 5-HT4 receptors.

Lesion Study of the Distribution of Serotonin 5‐HT4 Receptors in Rat Basal Ganglia and Hippocampus

  • V. CompanAnnie DaszutaPascal SalinMichèle SebbenJ. BockaertAline Dumuis
  • Biology
    The European journal of neuroscience
  • 1996
The regional distribution of 5‐hydroxytryptamine (5‐HT4) receptors labelled with [3H]GR113808 was examined in rat basal ganglia and hippocampus after specific lesions, indicating that striatal neurons belonging to the cortico‐striato‐nigrotectal pathway, and containing GABA and dynorphin, express 5‐ HT4 receptors.