The Effects of N-Methyl-D-Aspartate Agonists and Antagonists on Isolated Bovine Cerebral Arteries

@article{Wendling1996TheEO,
  title={The Effects of N-Methyl-D-Aspartate Agonists and Antagonists on Isolated Bovine Cerebral Arteries},
  author={Woodrow W. Wendling and D. Chen and Felicia B. Daniels and Madhavi Monteforte and Matthias Fischer and Concetta Harakal and Christer Carlsson},
  journal={Anesthesia \& Analgesia},
  year={1996},
  volume={82},
  pages={264-268.}
}
This pharmacologic study examines the direct cerebrovascular effects of N-methyl-D-aspartate (NMDA) receptor agonists and antagonists to determine whether large cerebral arteries have NMDA receptors. Bovine middle cerebral arteries were cut into rings to measure isometric tension development in vitro. Two competitive agonists, L-glutamate and NMDA, each had negligible effects on ring tension in the absence of exogenous vasoconstrictors. L-glutamate (in high concentrations) produced direct… 
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