The Effects of Morphine, MK-801, an NMDA Antagonist, and CP-96,345, an NK1 Antagonist, on the Hyperesthesia Evoked by Carageenan Injection in the Rat Paw

@article{Yamamoto1993TheEO,
  title={The Effects of Morphine, MK-801, an NMDA Antagonist, and CP-96,345, an NK1 Antagonist, on the Hyperesthesia Evoked by Carageenan Injection in the Rat Paw},
  author={Tatsuya Yamamoto and Naohito Shimoyama and Tadanobu Mizuguchi},
  journal={Anesthesiology},
  year={1993},
  volume={78 1},
  pages={
          124-33
        }
}
BACKGROUND The spinal mechanisms underlying the hyperesthetic state during inflammation are little understood. To gain a better understanding of these mechanisms, this study evaluated the effects of intrathecal morphine; MK-801, an N-methyl-D aspartic (NMDA) antagonist; and CP-96,345, an NK1 antagonist, on the hyperesthesia observed after carageenan injection of the rat paw. METHODS In rats injected with 2 mg carageenan, the paw withdrawal latency (PWL) for the injected paw was typically 5-6… CONTINUE READING
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