The Effects of Metformin and EGCG On PANC-1 Cell Survival.

@article{Hodges2015TheEO,
  title={The Effects of Metformin and EGCG On PANC-1 Cell Survival.},
  author={Victoria Hodges and Michelle A. Tucci and Hamed A. Benghuzzi},
  journal={Biomedical sciences instrumentation},
  year={2015},
  volume={51},
  pages={393-9}
}
There is less than a thirty percent survival rate for patients with a localized pancreatic tumor, and less than a ten percent survival rate for patients with metastases. Patients with pancreatic cancer often have altered glucose metabolism and are prescribed metformin which has been shown to reduce cancer cell proliferation. Metformin administered at doses ranging between 10-20 mM has been reported in the literature to induce AMPK signaling pathways which increase cellular apoptosis… CONTINUE READING