The Effects of Melatonin in Patients with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial

@article{Pakravan2017TheEO,
  title={The Effects of Melatonin in Patients with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial},
  author={Hassan Pakravan and Mehdi Ahmadian and Ali Fani and Davood Aghaee and Sareh Brumanad and Bahram Pakzad},
  journal={Advanced Biomedical Research},
  year={2017},
  volume={6}
}
Background: This study was designed to evaluate the effect of melatonin on nonalcoholic fatty liver disease (NAFLD) in compared to placebo. Materials and Methods: A total of 100 patients with histopathological diagnosis NAFLD in two groups of case and control received oral melatonin or placebo thrice daily for 3 months. Collected data were weight, waist, systolic blood pressure (SBP), diastolic blood pressure (DBP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), high… 

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References

SHOWING 1-10 OF 31 REFERENCES

Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: A randomized, controlled trial

Lifestyle intervention with diet and increased physical activity induces weight loss and is associated with a significant improvement in liver histology and laboratory abnormalities in pediatric NAFLD, which does not seem to increase the efficacy of lifestyle intervention alone.

The pilot study of 3-month course of melatonin treatment of patients with nonalcoholic steatohepatitis: effect on plasma levels of liver enzymes, lipids and melatonin.

It is demonstrated for the first time in humans that three months treatment with MT significantly improves plasma liver enzymes in patients with NASH without causing any side-effect.

Editorial: Effect of Atorvastatin, Vitamin E and C on Nonalcoholic Fatty Liver Disease: Is the Combination Required?

Nonalcoholic fatty liver disease is associated with the metabolic syndrome. The current standard of care, healthy diet and weight loss, has limited effect. The benefits of pharmacological treatments

Therapy of nonalcoholic fatty liver disease: current status.

Weight loss medication orlistat, ursodeoxycholic acid and antioxidant agents could potentially be used as adjunctive therapy and lifestyle modifications at present remain the only essential considerations in the NAFLD treatment.

The effects of long-term melatonin treatment on plasma liver enzymes levels and plasma concentrations of lipids and melatonin in patients with nonalcoholic steatohepatitis: a pilot study.

The results of the study demonstrating beneficial effect of melatonin on liver enzymes in patients with NASH would seem to encourage further controlled trials ofmelatonin given over a longer period of time with liver histology as end point.

Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis

Weight reduction achieved through lifestyle intervention leads to improvements in liver histology in NASH.

Melatonin ameliorates nonalcoholic fatty liver induced by high‐fat diet in rats

Melatonin exerts protective effects against fatty liver in rats induced by high‐fat diet possibly through its antioxidant actions, as shown in this study.

Effects of treatment with melatonin and tryptophan on liver enzymes, parameters of fat metabolism and plasma levels of cytokines in patients with non-alcoholic fatty liver disease--14 months follow up.

It is concluded that melatonin is worth considering for the therapy of NAFLD, particularly in patients with impaired fat metabolism accompanied by hypertriglyceridemia and hyper-LDL cholesterolemia.

Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis.

Vitamin E was superior to placebo for the treatment of nonalcoholic steatohepatitis in adults without diabetes, and significant benefits of pioglitazone were observed for some of the secondary outcomes.