The Effects of Lithium Chloride and Other Substances on Levels of Brain N-Acetyl-L-Aspartic Acid in Canavan Disease-Like Rats

@article{Baslow2002TheEO,
  title={The Effects of Lithium Chloride and Other Substances on Levels of Brain N-Acetyl-L-Aspartic Acid in Canavan Disease-Like Rats},
  author={Morris H. Baslow and Kazuhiro Kitada and Raymond F. Suckow and Basalingappa L. Hungund and Tadao Serikawa},
  journal={Neurochemical Research},
  year={2002},
  volume={27},
  pages={403-406}
}
Canavan disease (CD) is a human early-onset leukodystrophy, genetic in nature and resulting from an autosomally inherited recessive trait. CD is characterized by loss of the axon's myelin sheath, while leaving the axons intact, and spongiform degeneration, especially in white matter. It is an osmotic disease that affects both gray and white matter and is caused by the inability of oligodendrocytes to hydrolyze N-acetyl-L-aspartate (NAA) because of a lack of aspartoacylase activity. As a result… CONTINUE READING
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