The Effects of Ivermectin on Brugia malayi Females In Vitro: A Transcriptomic Approach

@inproceedings{Ballesteros2016TheEO,
  title={The Effects of Ivermectin on Brugia malayi Females In Vitro: A Transcriptomic Approach},
  author={Cristina Ballesteros and Lucienne Tritten and Maeghan O’Neill and Erica J. Burkman and Weam I. Zaky and Jianguo Xia and Andrew R. Moorhead and Steven E. Williams and Timothy G. Geary},
  booktitle={PLoS neglected tropical diseases},
  year={2016}
}
BACKGROUND Lymphatic filariasis and onchocerciasis are disabling and disfiguring neglected tropical diseases of major importance in developing countries. Ivermectin is the drug of choice for mass drug administration programs for the control of onchocerciasis and lymphatic filariasis in areas where the diseases are co-endemic. Although ivermectin paralyzes somatic and pharyngeal muscles in many nematodes, these actions are poorly characterized in adult filariae. We hypothesize that paralysis of… CONTINUE READING
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