The Effects of Ibogaine on Uterine Smooth Muscle Contractions: Relation to the Activity of Antioxidant Enzymes

@inproceedings{OreaninDui2018TheEO,
  title={The Effects of Ibogaine on Uterine Smooth Muscle Contractions: Relation to the Activity of Antioxidant Enzymes},
  author={Zorana Ore{\vs}{\vc}anin-Du{\vs}i{\'c} and Nikola Tatalovi{\'c} and Teodora Vidonja-Uzelac and Jelena Nestorov and Aleksandra Nikoli{\'c}-Koki{\'c} and Ana Miju{\vs}kovi{\'c} and Mihajlo Spasi{\'c} and Roman Pa{\vs}kulin and Mara Bresjanac and Du{\vs}ko Blagojevi{\'c}},
  booktitle={Oxidative medicine and cellular longevity},
  year={2018}
}
Ibogaine is an indole alkaloid originally extracted from the root bark of the African rainforest shrub Tabernanthe iboga. It has been explored as a treatment for substance abuse because it interrupts drug addiction and relieves withdrawal symptoms. However, it has been shown that ibogaine treatment leads to a sharp and transient fall in cellular ATP level followed by an increase of cellular respiration and ROS production. Since contractile tissues are sensitive to changes in the levels of ATP… CONTINUE READING

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