The Effects of Hepatotoxic Agents and of Liver Growth on the Urinary Excretion of the 7 V-Hydroxy Metabolite of 2-Acetylaminofluorene by Rats * ALFREDOMARGRETH

Abstract

Adult rats subjected to a number of treatments which cause liver damage and/or growth (administration of hepatotoxic agents, partial hepatectomy, or protein deple tion-repletion) and young growing rats excreted in the urine a greater percentage of a test dose of 2-acetylaminofluorene (AAF) as the carcinogenic Af-hydroxy metabolite than did normal adult rats… (More)

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