The Effects of Ethanol and Nicotine on Hepatic and Brain CYP2 Family Enzymes in African Green Monkeys

@inproceedings{Ferguson2014TheEO,
  title={The Effects of Ethanol and Nicotine on Hepatic and Brain CYP2 Family Enzymes in African Green Monkeys},
  author={Charmaine S. Ferguson},
  year={2014}
}
Cytochromes P450 (CYPs) metabolize a vast array of xenobiotics, including many drugs and toxins. Induction or downregulation of the CYPs can have important consequences such as changes in drug efficacy and altered susceptibility to toxicity. Our study investigated the independent and combined effects of ethanol and nicotine on hepatic and/or brain levels of CYP2E1, CYP2B6 and CYP2A6 in African green monkeys. Monkeys were randomized into four groups (N = 10/group): an ethanol-only group, a… CONTINUE READING

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 421 REFERENCES

Cytochrome P450 in the brain; a review.

VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL