The Effects of Estradiol on Central Serotonergic Systems and Its Relationship to Mood in Women

  title={The Effects of Estradiol on Central Serotonergic Systems and Its Relationship to Mood in Women},
  author={Gerri Lasiuk and Kathleen Mary Hegadoren},
  journal={Biological Research For Nursing},
  pages={147 - 160}
Lifetime prevalence rates of depression are higher in women than men. Because this gender disparity appears after the onset of puberty and declines after menopause, gonadal hormones may play a role in women's increased vulnerability to dysphoric states. Estrogens have powerful effects beyond their role in reproduction. Fluctuations in estrogen occur naturally throughout the reproductive years and can be associated with disruptions in mood. Treatment for depression with exogenous estrogen has… 

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