The Effects of Estradiol on Central Serotonergic Systems and Its Relationship to Mood in Women

@article{Lasiuk2007TheEO,
  title={The Effects of Estradiol on Central Serotonergic Systems and Its Relationship to Mood in Women},
  author={Gerri Lasiuk and Kathleen Mary Hegadoren},
  journal={Biological Research For Nursing},
  year={2007},
  volume={9},
  pages={147 - 160}
}
Lifetime prevalence rates of depression are higher in women than men. Because this gender disparity appears after the onset of puberty and declines after menopause, gonadal hormones may play a role in women's increased vulnerability to dysphoric states. Estrogens have powerful effects beyond their role in reproduction. Fluctuations in estrogen occur naturally throughout the reproductive years and can be associated with disruptions in mood. Treatment for depression with exogenous estrogen has… 
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Role of Estradiol in the Expression of Genes Involved in Serotonin Neurotransmission: Implications for Female Depression
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Estradiol increases tryptophan hydroxylase-2 and serotonin transporter expression and decreases the expres-sion of serotonin 1A receptor and monoamine oxidase A and B through the interaction with its intracellular receptors.
Comparison of the Effects of Estradiol and Progesterone on Serotonergic Function
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Targeting of ER beta or G-protein coupled receptor 30 might reveal a strategy to permit beneficial effects of estrogen without its deleterious effect on selective serotonin reuptake inhibitor efficacy.
Sex differences and the role of estrogen in animal models of schizophrenia: Interaction with BDNF
TLDR
It is posited estrogen-BDNF interaction could play a key role in modulating sex-dependent results reported in animal work as well as sex differences in clinical aspects of schizophrenia.
Depression during menopausal transition: a review of treatment strategies and pathophysiological correlates
TLDR
Evidence suggests that ovarian hormones modulate serotonin and noradrenaline neurotransmission, a process that may be associated with underlying pathophysiological processes involved in the emergence of depressive symptoms in biologically predisposed subpopulations.
Genetic variability in estrogen disposition: Potential clinical implications for neuropsychiatric disorders
  • S. Grover, P. Talwar, +6 authors R. Kukreti
  • Biology, Medicine
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2010
Variability in the physiological levels of neuroactive estrogens is widely believed to play a role in predisposition to several disorders of the central nervous system. Local biosynthesis of…
Association of sex hormones and sex hormone–binding globulin with depressive symptoms in postmenopausal women: the Multiethnic Study of Atherosclerosis
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In early postmenopausal women, sex hormones were associated with incident depressive symptoms and when stratified by HT use, results were consistent for HT users but attenuated for HT nonusers.
[Involvement of some subtypes of 5-HT2-receptors in affective behavior in female rats].
TLDR
The data obtained indicate a close interaction between the ovary hormonal and serotonergic systems of the brain in the mechanisms of anxiety and depression.
Temperament and ovarian reproductive hormones in women: Evidence from a study during the entire menstrual cycle
TLDR
Evidence is presented for an association between temperamental traits and woman's fecundity, as indicated by levels of ovarian steroid hormones during the menstrual cycle, linking personality and women's reproductive success through a hormonal pathway.
The importance of norepinephrine in depression
TLDR
Preclinical and clinical evidence suggest disturbances in serotonin (5-HT), norepinephrine (NE), and dopamine (DA) neurotransmission in the central nervous system contribute to depression.
Managing Depression during the Menopausal Transition.
The menopausal transition is associated with both first onset of depression and recurrent depression. Risk factors include vasomotor symptoms, a history of premenstrual dysphoria, postpartum…
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