The Effects of Diacerhein on Mechanical Allodynia in Inflammatory and Neuropathic Models of Nociception in Mice

@article{Quinto2005TheEO,
  title={The Effects of Diacerhein on Mechanical Allodynia in Inflammatory and Neuropathic Models of Nociception in Mice},
  author={Nara Lins Meira Quint{\~a}o and Rodrigo Medeiros and Adair R. S. Santos and Maria Martha Campos and Jo{\~a}o B. Calixto},
  journal={Anesthesia \& Analgesia},
  year={2005},
  volume={101},
  pages={1763-1769}
}
In this study we analyzed the systemic antiallodynic properties of diacerhein, a drug used to treat osteoarthritis, in inflammatory and neuropathic models of nociception in mice. The effects of diacerhein were compared with those of gabapentin, a drug used clinically for the management of neuropathic pain. Similar to gabapentin, diacerhein was able to significantly reverse the mechanical allodynia induced by carrageenan. A significant inhibition of carrageenan-induced nociception was also… Expand
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