The Effects of Curcumin on Aflatoxin B1- Induced Toxicity in Rats.

@article{Poapolathep2015TheEO,
  title={The Effects of Curcumin on Aflatoxin B1- Induced Toxicity in Rats.},
  author={Saranya Poapolathep and Kanjana Imsilp and Kenji Machii and Susumu Kumagai and Amnart Poapolathep},
  journal={Biocontrol science},
  year={2015},
  volume={20 3},
  pages={171-7}
}
To evaluate the potential of curcumin on toxic and carcinogenic effects of Aflatoxin B1 (AFB1) in relation to AFB1 metabolism, we studied the effects of curcumin on hepatic AFB1-DNA adduct formation and glutathione S-transferase (GST) activity, and the toxic effects of AFB1 in male Fischer 344 rats. Oral administration of curcumin to 5-week-old male rats at a dose of 8 or 80 mg/kg for five consecutive days for three weeks resulted in reduction of AFB1-DNA adduct formation mediated by both liver… CONTINUE READING

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