The Effects of Beta-Hydroxy-Beta-Methylbutyrate Supplementation on Recovery Following Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis

@article{Rahimi2018TheEO,
  title={The Effects of Beta-Hydroxy-Beta-Methylbutyrate Supplementation on Recovery Following Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis},
  author={Mohammad Hossein Rahimi and Hamed Mohammadi and Hesam Eshaghi and Gholamreza Askari and Maryam Miraghajani},
  journal={Journal of the American College of Nutrition},
  year={2018},
  volume={37},
  pages={640 - 649}
}
ABSTRACT Background: Growing evidence suggests beta-hydroxy-beta-methylbutyrate's (HMB) positive effects on recovery following exercise-induced muscle damage (EIMD). However, findings vary substantially across studies. Objective: A meta-analysis of randomized controlled trials was conducted to assess the effects of HMB supplementation on recovery following EIMD by assessing indirect markers of muscle damage, namely creatine kinase (CK) and lactate dehydrogenase (LDH) serum levels among healthy… Expand
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References

SHOWING 1-10 OF 89 REFERENCES
β-Hydroxy-β-methylbutyrate free acid reduces markers of exercise-induced muscle damage and improves recovery in resistance-trained men
TLDR
It is suggested that an HMB-FA supplement given to trained athletes before exercise can blunt increases in muscle damage and prevent declines in perceived readiness to train following a high-volume, muscle-damaging resistance-training session. Expand
b-Hydroxy-b-methylbutyrate free acid reduces markers of exercise-induced muscle damage and improves recovery in resistance-trained men
The purpose of the present study was to determine the effects of short-term supplementation with the free acid form of b-hydroxyb-methylbutyrate (HMB-FA) on indices of muscle damage, proteinExpand
Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review
TLDR
An in depth and objective analysis of HMB research is provided and a comprehensive discussion on possible mechanisms, which HMB may operate through is provided. Expand
Supplementation with beta-hydroxy-beta-methylbutyrate (HMB) and alpha-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man.
TLDR
14 d of HMB and KIC supplementation reduced signs and symptoms of exercise-induced muscle damage in non-resistance trained males following a single bout of eccentrically biased resistance exercise. Expand
The efficacy of a β-hydroxy-β-methylbutyrate supplementation on physical capacity, body composition and biochemical markers in elite rowers: a randomised, double-blind, placebo-controlled crossover study
TLDR
The results indicate that HMB intake in endurance training has an advantageous effect on the increase in aerobic capacity and the reduction of fat mass and on other indices of anaerobic adaptation and levels of investigated markers in the blood. Expand
Supplementation with β-Hydroxy-β-Methylbutyrate ( HMB ) and α-Ketoisocaproic Acid ( KIC ) Reduces Signs and Symptoms of Exercise-Induced Muscle Damage in Man
This study examined the effects of β-hydroxyβ-methylbutyrate (HMB) and α-ketoisocaproic acid (KIC) supplementation on signs and symptoms of exercise-induced muscle damage following a single bout ofExpand
The Effects of ß-Hydroxy-ß-Methylbutyrate (HMB) and HMB/Creatine Supplementation on Indices of Health in Highly Trained Athletes
TLDR
HMB and HMBCr were concluded to have no adverse effects on the parameters evaluated in this study when taken orally by highly trained male athletes over a 6-wk period. Expand
The Effect of a 12-Week Beta-hydroxy-beta-methylbutyrate (HMB) Supplementation on Highly-Trained Combat Sports Athletes: A Randomised, Double-Blind, Placebo-Controlled Crossover Study
TLDR
The results indicate that supplying HMB promotes advantageous changes in body composition and stimulates an increase in aerobic and anaerobic capacity in combat sports athletes. Expand
Beta-hydroxy-beta-methylbutyrate (HMB) supplementation does not affect changes in strength or body composition during resistance training in trained men.
TLDR
The data indicate that 6 weeks of HMB supplementation in either SH or TRH form does not influence changes in strength and body composition in response to resistance training in strength-trained athletes. Expand
Exercise-Induced Muscle Damage Is Not Attenuated by β-Hydroxy-β-Methylbutyrate and α-Ketoisocaproic Acid Supplementation
TLDR
Although 14 days HMB and KIC supplementation did not attenuate indices of EIMD after an acute bout of unaccustomed eccentric-biased exercise, there was a trend for a more rapid rate of recovery in isometric and isokinetic muscle function. Expand
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