The Effects of Aprotinin on Platelets In Vitro Using Whole Blood Flow Cytometry

@article{KozekLangenecker2000TheEO,
  title={The Effects of Aprotinin on Platelets In Vitro Using Whole Blood Flow Cytometry},
  author={Sibylle A. Kozek-Langenecker and Fazal S. Mohammad and Takahisa Masaki and Wayne Green and Craig D. Kamerath and Alfred K. Cheung},
  journal={Anesthesia \& Analgesia},
  year={2000},
  volume={90},
  pages={12–16}
}
We sought to evaluate the effects of aprotinin on the number and function of the platelet glycoprotein (GP) IIb–IIIa receptor and on the expression of P-selectin in vitro in order to gain insight into the potential mechanisms involved in the platelet-protective action of aprotinin during cardiopulmonary bypass. Aprotinin at 50 to 200 kallikrein inhibiting units/mL decreased the expression of activated GP IIb–IIIa complex in response to adenosine diphosphate or thrombin receptor activator… 
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TLDR
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