Corpus ID: 141916422

The Effects of Aniracetam Treatment on Cognitive Performance and AMPA Receptor GluR2 Subunit Expression After Moderate Fluid Percussion Injury in Rats

@inproceedings{Baranova2004TheEO,
  title={The Effects of Aniracetam Treatment on Cognitive Performance and AMPA Receptor GluR2 Subunit Expression After Moderate Fluid Percussion Injury in Rats},
  author={Anya Baranova},
  year={2004}
}
THE EFFECTS OF ANIRACETAM TREATMENT ON COGNITIVE PERFORMANCE AND AMPA RECEPTOR GLUR2 SUBUNIT EXPRESSION AFTER EXPERIMENTAL TBI IN RATS By Anna Baranova A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University Virginia Commonwealth University, 2004 Major Director: Robert J. Hamm, Ph. D., Department of Psychology In addition to the acute pathology produced by traumatic brain injury, there are chronic alterations… Expand

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TLDR
The positive effect of d-cycloserine against scopolamine-induced amnesia may be probably related to the cholinergic-glutamatergic interaction in the hippocampus, and the mechanism of positive action of aniracetam cannot be explained on the basis of AMPA receptor modulation, as the dose used is well below that required for the effect at AMPA receptors. Expand
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This investigation examined the effects of selective blockade of the presynaptic muscarinic M2 autoreceptor with BIBN 99 on cognitive recovery following rodent TBI and indicated that injured rats receiving the delayed post-injury treatment with B IBN 99 performed no better than injured-vehicle treated rats. Expand
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