Corpus ID: 141916422

The Effects of Aniracetam Treatment on Cognitive Performance and AMPA Receptor GluR2 Subunit Expression After Moderate Fluid Percussion Injury in Rats

  title={The Effects of Aniracetam Treatment on Cognitive Performance and AMPA Receptor GluR2 Subunit Expression After Moderate Fluid Percussion Injury in Rats},
  author={Anya Baranova},
THE EFFECTS OF ANIRACETAM TREATMENT ON COGNITIVE PERFORMANCE AND AMPA RECEPTOR GLUR2 SUBUNIT EXPRESSION AFTER EXPERIMENTAL TBI IN RATS By Anna Baranova A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University Virginia Commonwealth University, 2004 Major Director: Robert J. Hamm, Ph. D., Department of Psychology In addition to the acute pathology produced by traumatic brain injury, there are chronic alterations… Expand


Effects of D-cycloserine and Aniracetam on Spatial Learning in Rats with Entorhinal Cortex Lesions
The positive effect of d-cycloserine against scopolamine-induced amnesia may be probably related to the cholinergic-glutamatergic interaction in the hippocampus, and the mechanism of positive action of aniracetam cannot be explained on the basis of AMPA receptor modulation, as the dose used is well below that required for the effect at AMPA receptors. Expand
Post-injury administration of BIBN 99, a selective muscarinic M2 receptor antagonist, improves cognitive performance following traumatic brain injury in rats
This investigation examined the effects of selective blockade of the presynaptic muscarinic M2 autoreceptor with BIBN 99 on cognitive recovery following rodent TBI and indicated that injured rats receiving the delayed post-injury treatment with B IBN 99 performed no better than injured-vehicle treated rats. Expand
Neuroprotective effect of eliprodil: attenuation of a conditioned freezing deficit induced by traumatic injury of the right parietal cortex in the rat.
The data complement those previously published on the ability of eliprodil to reduce lesion volume following traumatic brain injury and show, in addition, that the neuroprotective effect has functional consequences. Expand
Amantadine improves water maze performance without affecting motor behavior following traumatic brain injury in rats.
The amantadine treatment regimen was ineffective in promoting motor recovery and increasing survival of hippocampal neurons in both the CA1 and CA3 regions following TBI, but did show improved swim latencies during the five days of water maze testing. Expand
Rivastigmine, a brain-selective acetylcholinesterase inhibitor, ameliorates cognitive and motor deficits induced by closed-head injury in the mouse.
The data show that the reduction by Rivastigmine of the immediate and long-term sequelae of brain injury are mediated by increased cholinergic activity at both muscarinic and nicotinic receptors. Expand
Effects of aniracetam on extracellular levels of transmitter amino acids in the hippocampus of the conscious gerbils: an intracranial microdialysis study
The results suggest that the effects of aniracetam on amino acid levels might be a mechanism of protection against delayed neuronal death in the ischemic hippocampus, thereby improving memory dysfunction induced by ischemia/reperfusion. Expand
Postinjury Administration of l -Deprenyl Improves Cognitive Function and Enhances Neuroplasticity after Traumatic Brain Injury
The results suggest that dopaminergic/noradrenergic enhancement facilitates cognitive recovery after brain injury and that nor adrenergic fiber integrity is correlated with enhanced synaptic plasticity in the injured hippocampus. Expand
Chronic Administration of a Partial Muscarinic M1Receptor Agonist Attenuates Decreases in Forebrain Choline Acetyltransferase Immunoreactivity Following Experimental Brain Trauma
The hypothesis that increasing cholinergic tone during the recovery period after TBI will restore ChAT-IR function impaired by brain trauma is supported. Expand
Aniracetam enhances glutamatergic transmission in the prefrontal cortex of stroke-prone spontaneously hypertensive rats
It is suggested that aniracetam enhances cortical glutamatergic release, which may be the mechanism involved in the ameliorating effects of anir acetam on various neuronal dysfunctions. Expand
The Sodium Channel Blocker and Glutamate Release Inhibitor BW1003C87 and Magnesium Attenuate Regional Cerebral Edema Following Experimental Brain Injury in the Rat
It is suggested that excitatory neurotransmission may play an important role in the pathogenesis of posttraumatic brain edema and that pre‐ or post‐synaptic blockade of glutamate receptor systems may attenuate part of the deleterious sequelae of traumatic brain injury. Expand