The Effects of Alpha-Tocopherol on Hippocampal Oxidative Stress Prior to in Pilocarpine-Induced Seizures

@article{Tom2009TheEO,
  title={The Effects of Alpha-Tocopherol on Hippocampal Oxidative Stress Prior to in Pilocarpine-Induced Seizures},
  author={Adriana da Rocha Tom{\'e} and Dejiang Feng and Rivelilson Mendes de Freitas},
  journal={Neurochemical Research},
  year={2009},
  volume={35},
  pages={580-587}
}
Reactive oxygen species have been implicated in seizure-induced neurodegeneration, and there is a correlation between free radical level and scavenger enzymatic activity in the epilepsy. It has been suggested that pilocarpine-induced seizures is mediated by an increase in oxidative stress. Current research has found that antioxidant may provide, in a certain degree, neuroprotection against the neurotoxicity of seizures at the cellular level. Alpha-tocopherol has numerous nonenzymatic actions… CONTINUE READING
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