The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pituitary Gland Pathology in Sprague—Dawley Rats

@article{MolonNoblot2003TheEO,
  title={The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pituitary Gland Pathology in Sprague—Dawley Rats},
  author={Sylvain Molon-Noblot and Philippe Laroque and John B. Coleman and Chao-Min Hoe and Kevin P. Keenan},
  journal={Toxicologic Pathology},
  year={2003},
  volume={31},
  pages={310 - 320}
}
  • Sylvain Molon-Noblot, Philippe Laroque, +2 authors Kevin P. Keenan
  • Published in Toxicologic pathology 2003
  • Biology, Medicine
  • Toxicologic Pathology
  • This study compared the effects of ad libitum (AL) overfeeding and moderate or marked dietary restriction (DR) on the pathogenesis of aged-related pituitary gland changes in Sprague—Dawley (SD) rats. SD rats were fed Purina Certified Rodent Diet AL (group 1), DR at 72—79% of AL (group 2), DR at 68—72% of AL (group 3) or DR at 47—48% of AL (group 4) for 106 weeks. Interim necropsies were performed at 13, 26, and 53 weeks, after a 7-day 5-bromo-2-deoxyuridine (BrdU)-filled minipump implantation… CONTINUE READING

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