The Effects of ß-Hydroxy-ß-Methylbutyrate (HMB) and HMB/Creatine Supplementation on Indices of Health in Highly Trained Athletes

  title={The Effects of {\ss}-Hydroxy-{\ss}-Methylbutyrate (HMB) and HMB/Creatine Supplementation on Indices of Health in Highly Trained Athletes},
  author={Melissa J Crowe and Donna O’Connor and Joann E. Lukins},
  journal={International Journal of Sport Nutrition and Exercise Metabolism},
This study aimed to investigate the effects of 6 wk oral supplementation of beta-hydroxy-beta-methylbutyrate (HMB) and HMB combined with creatine monohydrate (HMBCr) on indices of health in highly trained athletes. Elite, male rugby league players (n=28) were allocated to 1 of 3 groups: a control group (n=6), a HMB group (3 g/d; n=11), or a HMBCr group (3 g/day HMB, 3 g/d Cr; n=11). Testing prior to, and immediately following, supplementation included a full blood count, plasma testosterone and… 


HMB and HMBCr were concluded to have no ergogenic effect on muscular strength and endurance, leg power, or anthropometry when taken orally by highly trained male athletes over 6 weeks.

Long-Term Effect of Combination of Creatine Monohydrate Plus β-Hydroxy β-Methylbutyrate (HMB) on Exercise-Induced Muscle Damage and Anabolic/Catabolic Hormones in Elite Male Endurance Athletes

The combination of CrM plus HMB showed an increase in testosterone and T/C compared with the other groups after 10 weeks of supplementation and presented a synergistic effect on testosterone and the testosterone/cortisol ratio and an antagonistic effect with respect to the sum of individual or isolated supplementation.

The Effect of a 12-Week Beta-hydroxy-beta-methylbutyrate (HMB) Supplementation on Highly-Trained Combat Sports Athletes: A Randomised, Double-Blind, Placebo-Controlled Crossover Study

The results indicate that supplying HMB promotes advantageous changes in body composition and stimulates an increase in aerobic and anaerobic capacity in combat sports athletes.

The efficacy of a β-hydroxy-β-methylbutyrate supplementation on physical capacity, body composition and biochemical markers in elite rowers: a randomised, double-blind, placebo-controlled crossover study

The results indicate that HMB intake in endurance training has an advantageous effect on the increase in aerobic capacity and the reduction of fat mass and on other indices of anaerobic adaptation and levels of investigated markers in the blood.

Effect of Ten Weeks of Creatine Monohydrate Plus HMB Supplementation on Athletic Performance Tests in Elite Male Endurance Athletes

CrM plus HMB supplementation over 10 weeks showed a synergistic effect on aerobic power during an incremental test but had no influence muscle mass, as measured as WAT, W4, and W8.

β-Hydroxy β-methylbutyrate free acid alters cortisol responses, but not myofibrillar proteolysis, during a 24-h fast

HMB-FA may affect cortisol responses, but not myofibrillar proteolysis, during acute 24-h fasting, in a randomised, double-blind, placebo-controlled cross-over trial.

The Effect of &bgr;-Hydroxy-&bgr;-Methylbutyrate on Aerobic Capacity and Body Composition in Trained Athletes

The results indicate that supplying HMB promotes advantageous changes in body composition and stimulates an increase in aerobic capacity, although seeming not to significantly affect the levels of the analyzed blood markers.

The Effects of Beta-Hydroxy-Beta-Methylbutyrate Supplementation on Recovery Following Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis

The current evidence revealed a time-dependent effect of HMB in reducing LDH and CK serum levels among adults, and HMB may be seen as a priority muscle damage recovery agent in interventions.

Effect of the Combination of Creatine Monohydrate Plus HMB Supplementation on Sports Performance, Body Composition, Markers of Muscle Damage and Hormone Status: A Systematic Review

In summary, the combination of 3–10 g/day of CrM plus HMB for 1–6 weeks could produce potential positive effects on sport performance (strength and anaerobic performance) and for 4 weeks on body composition (increasing fat free mass and decreasing fat mass).

Beta-hydroxy-beta-methylbutyrate supplementation in health and disease: a systematic review of randomized trials

Most of the selected studies showed the effectiveness of HMB in preventing exercise-related muscle damage in healthy trained and untrained individuals as well as muscle loss during chronic diseases.



Effects of calcium beta-hydroxy-beta-methylbutyrate (HMB) supplementation during resistance-training on markers of catabolism, body composition and strength.

Results indicate that 28 d of HMB supplementation during resistance-training does not reduce catabolism or affect training-induced changes in body composition and strength in experienced resistance-trained males.

β-Hydroxy-β-Methylbutyrate (HMB) Supplementation in Humans Is Safe and May Decrease Cardiovascular Risk Factors

Objective data collected across nine experiments indicate that HMB can be taken safely as an ergogenic aid for exercise and that objective measures of health and perception of well-being are generally enhanced.

Nutritional supplementation of the leucine metabolite beta-hydroxy-beta-methylbutyrate (hmb) during resistance training.

This study showed, regardless of gender or training status, HMB may increase upper body strength and minimize muscle damage when combined with an exercise program.

Beta-hydroxy beta-methylbutyrate (HMB) supplementation does not influence the urinary testosterone: epitestosterone ratio in healthy males.

The results support the claim that supplementation with HMB at the doses recommended will not influence the urinary testosterone: epitestosterone ratio and thus not breach doping policies of the International Olympic Committee for exogenous testosterone or precursor administration.

Effects of beta-hydroxy-beta-methylbutyrate on muscle damage after a prolonged run.

The hypothesis that HMB supplementation helps prevent exercise-induced muscle damage is supported and supplementation with 3.0 g of HMB results in a decreased creatine phosphokinase and LDH response after a prolonged run.

Beta-hydroxy-beta-methylbutyrate ingestion, part II: effects on hematology, hepatic and renal function.

Data indicate that 8 wk of HMB supplementation during resistance training had no adverse affects on hepatic enzyme function, lipid profile, renal function, or the immune system.

β-Hydroxy-β-Methylbutyrate (HMB) Supplementation and the Promotion of Muscle Growth and Strength

There is clearly a need for more tightly controlled, longer duration studies to verify if HMB enhances strength and muscular hypertrophy development associated with resistance training across a range of groups, including resistance trained individuals.

Effects of creatine supplementation on body composition, strength, and sprint performance.

The addition of creatine to the glucose/taurine/electrolyte supplement promoted greater gains in fat/bone-free mass, isotonic lifting volume, and sprint performance during intense resistance/agility training.


Examination of five days of creatine loading followed by five weeks of maintenance during weight training and its affect on hepatic enzymes that mark liver stress indicated that the changes noted were not statistically significant and remained within normal clinical ranges.