The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length


Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10(-9), two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.

DOI: 10.1093/jnci/dju267

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@inproceedings{Iles2014TheEO, title={The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length}, author={Mark M. Iles and D Timothy Bishop and John C. Taylor and Nicholas Hayward and Myriam Brossard and Anne E Cust and Alison M. Dunning and Jeffrey E. Lee and Eric K. Moses and Lars Andreas Akslen and Per Arne Andresen and Marie-Françoise M Avril and Esther Azizi and Giovanna Bianchi Scarr{\`a} and Kevin M Brown and Tadeusz Dȩbniak and David E. Elder and Eitan Friedman and Paola Ghiorzo and Elizabeth Gillanders and Alisa M. Goldstein and Nelleke A. Gruis and Johan Hansson and Mark Harland and Per Helsing and Marko Hocevar and Veronica H{\"{o}iom and Christian Ingvar and Peter A. Kanetsky and Maria Teresa Landi and Julie M Lang and G. M. Lathrop and Jan Lubiński and Rona M. MacKie and Nicholas G. Martin and Anders Molven and Grant W. Montgomery and Srdjan Novakovic and H{\aa}kan Olsson and Susana Puig and Joan Anton Puig-Butill{\'e} and Graham L. Radford-Smith and Juliette A Randerson-Moor and Nienke van der Stoep and Remco van Doorn and David C Whiteman and Stuart MacGregor and Karen A. Pooley and Sarah Ward and Graham J. Mann and Christopher I. Amos and Paul D. P. Pharoah and Florence Demenais and Matthew H Law and Julia A. Newton Bishop and Jennifer H. Barrett}, booktitle={Journal of the National Cancer Institute}, year={2014} }