The Effect of the Phytoestrogens Genistein, Daidzein, and Equol on the Growth of Tamoxifen-Resistant T47D/PKCα

@article{Tonetti2007TheEO,
  title={The Effect of the Phytoestrogens Genistein, Daidzein, and Equol on the Growth of Tamoxifen-Resistant T47D/PKCα},
  author={D. Tonetti and Y. Zhang and H. Zhao and S. Lim and A. Constantinou},
  journal={Nutrition and Cancer},
  year={2007},
  volume={58},
  pages={222 - 229}
}
  • D. Tonetti, Y. Zhang, +2 authors A. Constantinou
  • Published 2007
  • Chemistry, Medicine
  • Nutrition and Cancer
  • Abstract Soy supplements are often consumed by women for alleviating menopausal symptoms or for the perceived protective effects against breast cancer. More concerning is the concurrent consumption of soy isoflavones with tamoxifen (TAM) for prevention or treatment of breast cancer. We previously described a T47D:A18/protein kinase C (PKC)α TAM-resistant tumor model that exhibits autonomous growth and estradiol-induced tumor regression. We compared the estrogenicity of the isoflavones genistein… CONTINUE READING
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