The Effect of mGluR5 Antagonism During Binge Drinkingon Subsequent Ethanol Intake in C57BL/6J Mice: Sex- and Age-Induced Differences.

@article{Cozzoli2014TheEO,
  title={The Effect of mGluR5 Antagonism During Binge Drinkingon Subsequent Ethanol Intake in C57BL/6J Mice: Sex- and Age-Induced Differences.},
  author={Debra K. Cozzoli and Moriah N. Strong-Kaufman and Michelle A. Tanchuck and Joel G. Hashimoto and Kristine M. Wiren and Deborah A. Finn},
  journal={Alcoholism, clinical and experimental research},
  year={2014},
  volume={38 3},
  pages={
          730-738
        }
}
BACKGROUND Binge ethanol (EtOH) intake during adolescence leads to an array of behavioral and cognitive consequences including elevated intake of EtOH during adulthood, with female mice showing greater susceptibility than males. Administration of the metabotropic glutamate receptor 5 (mGluR5) antagonist 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine (MTEP) has been shown to reduce EtOH self-administration in adult male mice, but little is known about its effect on female and adolescent mice… CONTINUE READING
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