The Effect of c-Fos Demethylation on Sodium Fluoride-induced Apoptosis in L-02 Cells

  title={The Effect of c-Fos Demethylation on Sodium Fluoride-induced Apoptosis in L-02 Cells},
  author={Qiang Niu and Hongliang Liu and Zhi-Zhong Guan and Qiang Zeng and Shuxia Guo and Ping He and Lijuan Guo and Ping Gao and Bayi Xu and Zhixia Xu and Tao Xia and Aiguo Wang},
  journal={Biological Trace Element Research},
To investigate the effects of sodium fluoride (NaF) on apoptosis, c-Fos mRNA and protein expression levels, and methylation status as well as Dnmt1, Dnmt3a, and Dnmt3b mRNA expression levels in human embryo hepatocyte (L-02) which were exposed to different concentrations of NaF (0, 20, 40, and 80 mg/l) for 24 h in vitro. Results showed that the percentage of apoptosis and c-Fos mRNA and protein expression levels in 40 and 80 mg/l NaF-treated groups were higher than those in the control group (P… CONTINUE READING


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