The Effect of a Single Dose of Quazepam (Sch-16134) on the Sleep of Chronic Insomniacs
@article{Roth1979TheEO,
title={The Effect of a Single Dose of Quazepam (Sch-16134) on the Sleep of Chronic Insomniacs},
author={Thomas Roth and E I Tietz and Milton Kramer and M Kaffeman},
journal={Journal of International Medical Research},
year={1979},
volume={7},
pages={583 - 587}
}The present study evaluated the efficacy of 25 mg of quazepam, a new benzodiazepine hypnotic, in a population of chronic insomniacs. The results indicate that a single dose (25 mg) administered for one night was efficacious when measured both objectively by polysomnographic recording and subjectively by questionnaire with no reported side-effects. The change in the objective measures paralleled the direction of change in subjective measures. Sleep efficiency and sleep maintenance were improved…
18 Citations
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SummaryThe hypnotic effect and tolerance of quazepam (Sch 16134) 15 and 30 mg, flunitrazepam 1 and 2 mg and placebo were evaluated in a one-night, randomized, double-blind, parallel group study of…
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Quazepam is a benzodiazepine hypnotic that can be useful in the adjunctive pharmacologic treatment of insomnia and is more effective with short‐term use, and with continued use it maintains its efficacy in contrast to both of these drugs which show rapid development of tolerance.
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Preliminary evidence suggests that quazepam 15 to 30 mg is as effective as flurAZepam and triazolam in usual therapeutic doses, and causes minimal rebound insomnia following its withdrawal, unlike rapidly eliminated benzodiazepines such as triazlam.
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The purpose of this review is to provide an update on distinguishing features of quazepam with regard to its pharmacology, pharmacokinetics, sleep efficacy and potential adverse effects compared to other agents used for insomnia.
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