The Effect of a Single Dose of Quazepam (Sch-16134) on the Sleep of Chronic Insomniacs
@article{Roth1979TheEO, title={The Effect of a Single Dose of Quazepam (Sch-16134) on the Sleep of Chronic Insomniacs}, author={Thomas Roth and E I Tietz and Milton Kramer and M Kaffeman}, journal={Journal of International Medical Research}, year={1979}, volume={7}, pages={583 - 587} }
The present study evaluated the efficacy of 25 mg of quazepam, a new benzodiazepine hypnotic, in a population of chronic insomniacs. The results indicate that a single dose (25 mg) administered for one night was efficacious when measured both objectively by polysomnographic recording and subjectively by questionnaire with no reported side-effects. The change in the objective measures paralleled the direction of change in subjective measures. Sleep efficiency and sleep maintenance were improved…
18 Citations
A Clinical Study of Quazepam in Hospitalized Patients with Insomnia
- Medicine, PsychologyThe Journal of international medical research
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Quazepam demonstrated greater improvement in Hypnotic Activity Index and Sleep Quality Index from baseline scores, and caused no adverse reactions.
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It is demonstrated that quazepam, in a 15 mg dose, is an effective, rapidly acting, oral hypnotic agent with a low incidence of adverse effects.
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SummaryThe hypnotic effect and tolerance of quazepam (Sch 16134) 15 and 30 mg, flunitrazepam 1 and 2 mg and placebo were evaluated in a one-night, randomized, double-blind, parallel group study of…
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Performance scores were already showing recovery from peak impairment 2 h post-drug ingestion, although quazepam's potent N-desalkylflurazepAM metabolite has been found to maintain a maximum plateau level from 2 to 24 h.
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