The Effect of a Nonabsorbed Oral Antibiotic (Rifaximin) on the Symptoms of the Irritable Bowel Syndrome

@article{Pimentel2006TheEO,
  title={The Effect of a Nonabsorbed Oral Antibiotic (Rifaximin) on the Symptoms of the Irritable Bowel Syndrome},
  author={Mark Pimentel and Sandy Park and J Mirocha and Sunanda V Kane and Yuthana Kong},
  journal={Annals of Internal Medicine},
  year={2006},
  volume={145},
  pages={557-563}
}
Context Few trials have evaluated the effects of antibiotics on symptoms of the irritable bowel syndrome (IBS). Contribution In this double-blind trial, 87 patients with IBS were randomly assigned to either rifaximin (400 mg 3 times daily) or placebo for 10 days. Over a 10-week follow-up period, the rifaximin recipients reported global improvements in overall symptoms and less bloating more frequently than the placebo recipients. No major differences in abdominal pain, diarrhea, or constipation… 
Rifaximin therapy for patients with irritable bowel syndrome without constipation.
TLDR
Among patients who had IBS without constipation, treatment with rifaximin for 2 weeks provided significant relief of IBS symptoms, bloating, abdominal pain, and loose or watery stools.
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TLDR
Rifaximin offers a potential new therapeutic option for patients with refractory IBS, and in some cases, correlated with reductions in hydrogen breath tests, suggesting successful treatment of bacterial overgrowth.
Efficacy of Rifaximin, a Nonabsorbed Oral Antibiotic, in the Treatment of Small Intestinal Bacterial Overgrowth
TLDR
Rifaximin in a dose of 800 mg per day for 4 weeks was safe and effective treatment in reducing symptoms in patients with SIBO of multiple etiologies, especially when diarrhea was the dominant symptom and normalized the glucose breath test in approximately 50% of patients.
Non-Absorbed Antibiotic for Irritable Bowel Syndrome
  • B. Cash
  • Medicine
    Current gastroenterology reports
  • 2011
TLDR
This report represents pooled data from two identical phase 3, double-blind, placebo-controlled, multicenter trials in which patients with non-constipated IBS were randomized to receive rifaximin or placebo three times a day for 2 weeks.
Profile of rifaximin and its potential in the treatment of irritable bowel syndrome
TLDR
Clinical studies have demonstrated that rifaximin improves symptoms associated with IBS, such as bloating, flatulence, stool consistency, and abdominal pain, and has a side-effect profile similar to placebo, which presents as a safe and beneficial addition to the current management options for IBS.
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TLDR
Rifaximin, with its low systemic absorption and no clinically significant interactions with other drugs, may represent a treatment of choice for IBS, mainly due to its ability to act on IBS pathogenesis, through the modulation of gut microbiota.
Repeat Treatment With Rifaximin Is Safe and Effective in Patients With Diarrhea-Predominant Irritable Bowel Syndrome.
TLDR
In a phase 3 study of patients with relapsing symptoms of IBS-D, repeat rifaximin treatment was efficacious and well tolerated and significant improvements were noted for prevention of recurrence, durable response, and bowel movement urgency.
Rifaximin for the treatment of irritable bowel syndrome – a drug safety evaluation
TLDR
Rifaximin is a non-absorbable antibiotic with additional anti-inflammatory and gut microbiota-modulating activity that is effective in inducing symptoms relief in patients with IBS, even after repeated treatment courses.
Mechanism of action and therapeutic benefit of rifaximin in patients with irritable bowel syndrome: a narrative review
TLDR
Current studies indicate that rifaximin induces only modest effects on the gut microbiota of patients with IBS-D, suggesting that the efficacy of rifaxin may involve other mechanisms, and further study is needed.
Repeat Rifaximin for Irritable Bowel Syndrome: No Clinically Significant Changes in Stool Microbial Antibiotic Sensitivity
TLDR
Rifaximin exposure was not associated with long-term cross-resistance of Bacteroidaceae, Enterobacteriaceae, and Enterococcaceae to rifampin or nonrifamycin antibiotics tested.
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