The Effect of a DNA Repair Gene on Cellular Invasiveness: Xrcc3 Over-Expression in Breast Cancer Cells

@inproceedings{MartinezMarignac2011TheEO,
  title={The Effect of a DNA Repair Gene on Cellular Invasiveness: Xrcc3 Over-Expression in Breast Cancer Cells},
  author={Veronica L. Martinez-Marignac and Amelie A Rodrigue and David Davidson and Martin Couillard and Ala-Eddin Al-Moustafa and Mark Abramovitz and William D Foulkes and J Masson and Raquel S. Aloyz},
  booktitle={PloS one},
  year={2011}
}
Over-expression of DNA repair genes has been associated with resistance to radiation and DNA-damage induced by chemotherapeutic agents such as cisplatin. More recently, based on the analysis of genome expression profiling, it was proposed that over-expression of DNA repair genes enhances the invasive behaviour of tumour cells. In this study we present experimental evidence utilizing functional assays to test this hypothesis. We assessed the effect of the DNA repair proteins known as X-ray… CONTINUE READING

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