The Effect of Water Plasticization on the Molecular Mobility and Crystallization Tendency of Amorphous Disaccharides

@article{Heljo2011TheEO,
  title={The Effect of Water Plasticization on the Molecular Mobility and Crystallization Tendency of Amorphous Disaccharides},
  author={Ville Petteri Heljo and Antti Nordberg and Mikko Tenho and Tommi Virtanen and Kirsi Jouppila and Jarno Salonen and Sirkka Liisa Maunu and Anne Mari Juppo},
  journal={Pharmaceutical Research},
  year={2011},
  volume={29},
  pages={2684-2697}
}
To study how water plasticization affects the molecular mobility and crystallization tendency of freeze-dried trehalose, sucrose, melibiose and cellobiose. Freeze-dried disaccharides were subjected to different relative humidity atmospheres and their physical stabilities were evaluated. Lyophilizate water sorption tendencies and glass transition temperatures were modeled using Brunauer-Emmett-Teller (BET) and Gordon-Taylor (GT) equations, respectively. Sucrose and cellobiose crystallization… CONTINUE READING
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