The Effect of Verapamil on the Pharmacokinetic Disposition of Theophylline in Cigarette Smokers

  title={The Effect of Verapamil on the Pharmacokinetic Disposition of Theophylline in Cigarette Smokers},
  author={Azusa Gin and Kathleen A. Stringer and Lynda S. Welage and John H. Wilton and G E Matthews},
  journal={The Journal of Clinical Pharmacology},
In a randomized cross‐over study the effect of verapamil on the pharmacokinetics of theophylline was evaluated in eight cigarette smoking male volunteers. Theophylline was administered as an intravenous infusion of aminophylline, 6 mg/kg based on ideal body weight, over 30 minutes in the control phase. In the treatment phase, aminophylline was administered after a four day regimen of oral verapamil 80 mg every 8 hours. Serial blood samples were collected over a 24 hour period following… 

The effect of three different oral doses of verapamil on the disposition of theophylline

The results suggest that the inhibitory effect of verapamil on the pharmacokinetic disposition of theophylline is directly related to verAPamil dose.

Influence of Endogenous and Exogenous Effectors on the Pharmacokinetics of Theophylline

Age and concomitant disease are the major endogenous effectors influencing biotransformation of theophylline, whereas biorhythms, gender and pregnancy are of lesser importance.

Theophylline and Verapamil: Clinically Significant Drug Interaction

Although the most recent FDA labeling guidelines for theophylline mention verapamil as a documented source of drug interaction with theophyLLine, many clinicians may not realize the potential clinical significance of this interaction.

Pharmacokinetic Interactions with Calcium Channel Antagonists (Part I)

Interactions between calcium antagonists and marker compounds, theophylline, midazolam, lithium, doxorubicin, oral hypoglycaemics and cardiac drugs are dealt with.

Pharmacokinetic Interactions Between Theophylline and Other Medication (Part II)

The effects or lack of effects on theophylline clearance of sympathomimetics, corticosteroids, antihistamines and other antiallergy drugs, antimicrobial agents, Phenytoin, carbamazepine, barbiturates, antacids and activated charcoal are covered.



Effect of calcium channel blockers on theophylline disposition

The modest reduction in theophylline clearance observed after verapamil and diltiazem is not likely to produce clinically significant increases in thephylline concentrations in most patients.

The influence of cigarette smoking and sex on theophylline disposition.

The effects of cigarette smoking and sex on theophylline clearance, elimination rate constant, and apparent volume of distribution were examined in 28 healthy, young adults given single oral doses of

Selective inhibitory effects of nifedipine and verapamil on oxidative metabolism: effects on theophylline.

Verapamil and nifedipine at usual clinical doses are unlikely to cause clinically significant changes in theophylline disposition.

Changes in antipyrine and indocyanine green kinetics during nifedipine, verapamil, and diltiazem therapy

Drug interactions with other liver‐metabolized drugs may occur during therapy with these calcium antagonists and nifedipine appears to increase liver blood flow whereas diltiazem inhibits oxidative drug metabolism.

Substrate-selective inhibition by verapamil and diltiazem: differential disposition of antipyrine and theophylline in humans.

Antipyrine and theophylline disposition was studied in healthy volunteer subjects in the control state while the subjects were taking verapamil orally four times daily or diltiazem orally three times daily, resulting in prolonged antipyrine half-life with no change in distribution volume.

Enhanced biotransformation of theophylline in marihuana and tobacco smokers

Concern over enhanced metabolism of other drugs is probably warranted in tobacco and cannabis smokers and theophylline was cleared from the blood more rapidly in both marihuana and tobacco smokers.

Influence of cigarette smoking on drug metabolism in man.

  • W. Jusko
  • Medicine, Biology
    Drug metabolism reviews
  • 1979
Smoking is only one of numerous factors which can perturb hepatic biotransformation as patient surveillance studies show that age and cardiac and liver disease may be of greater importance in actual patients undergoing therapy.

Calcium Antagonists in the Management of Asthma: Breakthrough or Ballyhoo?

Data has been generated on the effects of verapamil, diltiazem, nifedipine, and several investigational agents on experimentally induced asthma, indicating that none of these agents significantly affects resting bronchomotor tone, and their efficacy in preventing bronchospasm is a function of the drug, dose, route of administration and method of bronchoprovocation.

Induction and inhibition of drug metabolism

The metabolism of drugs is substantially influenced by the deliberate or passive intake of many chemical substances that Man is increasingly being exposed to either in his environment, for medical reasons or as a result of his life style.