The Effect of Verapamil on the Pharmacokinetic Disposition of Theophylline in Cigarette Smokers

@article{Gin1989TheEO,
  title={The Effect of Verapamil on the Pharmacokinetic Disposition of Theophylline in Cigarette Smokers},
  author={Azusa Gin and Kathleen A. Stringer and Lynda S. Welage and John H. Wilton and G E Matthews},
  journal={The Journal of Clinical Pharmacology},
  year={1989},
  volume={29}
}
In a randomized cross‐over study the effect of verapamil on the pharmacokinetics of theophylline was evaluated in eight cigarette smoking male volunteers. Theophylline was administered as an intravenous infusion of aminophylline, 6 mg/kg based on ideal body weight, over 30 minutes in the control phase. In the treatment phase, aminophylline was administered after a four day regimen of oral verapamil 80 mg every 8 hours. Serial blood samples were collected over a 24 hour period following… 

The effect of three different oral doses of verapamil on the disposition of theophylline

The results suggest that the inhibitory effect of verapamil on the pharmacokinetic disposition of theophylline is directly related to verAPamil dose.

Influence of Endogenous and Exogenous Effectors on the Pharmacokinetics of Theophylline

Age and concomitant disease are the major endogenous effectors influencing biotransformation of theophylline, whereas biorhythms, gender and pregnancy are of lesser importance.

Theophylline and Verapamil: Clinically Significant Drug Interaction

Although the most recent FDA labeling guidelines for theophylline mention verapamil as a documented source of drug interaction with theophyLLine, many clinicians may not realize the potential clinical significance of this interaction.

Pharmacokinetic Interactions with Calcium Channel Antagonists (Part I)

Interactions between calcium antagonists and marker compounds, theophylline, midazolam, lithium, doxorubicin, oral hypoglycaemics and cardiac drugs are dealt with.

Pharmacokinetic Interactions Between Theophylline and Other Medication (Part II)

The effects or lack of effects on theophylline clearance of sympathomimetics, corticosteroids, antihistamines and other antiallergy drugs, antimicrobial agents, Phenytoin, carbamazepine, barbiturates, antacids and activated charcoal are covered.

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Data has been generated on the effects of verapamil, diltiazem, nifedipine, and several investigational agents on experimentally induced asthma, indicating that none of these agents significantly affects resting bronchomotor tone, and their efficacy in preventing bronchospasm is a function of the drug, dose, route of administration and method of bronchoprovocation.

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