The Effect of Verapamil on the Pharmacokinetic Disposition of Theophylline in Cigarette Smokers

@article{Gin1989TheEO,
  title={The Effect of Verapamil on the Pharmacokinetic Disposition of Theophylline in Cigarette Smokers},
  author={Azusa Gin and Kathleen A. Stringer and Lynda S. Welage and John H. Wilton and G E Matthews},
  journal={The Journal of Clinical Pharmacology},
  year={1989},
  volume={29}
}
In a randomized cross‐over study the effect of verapamil on the pharmacokinetics of theophylline was evaluated in eight cigarette smoking male volunteers. Theophylline was administered as an intravenous infusion of aminophylline, 6 mg/kg based on ideal body weight, over 30 minutes in the control phase. In the treatment phase, aminophylline was administered after a four day regimen of oral verapamil 80 mg every 8 hours. Serial blood samples were collected over a 24 hour period following… Expand
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