The Effect of Verapamil and Diltiazem on Alveolar Type II Cells during Warm and Cold Metabolic Ischaemia

@article{Spaggiari1994TheEO,
  title={The Effect of Verapamil and Diltiazem on Alveolar Type II Cells during Warm and Cold Metabolic Ischaemia},
  author={Lorenzo Spaggiari and Michele Rusca and Roberta Alfieri and Pier Giorgio Petronini and Paolo Carbognani and Leonardo Cattelani and Angelo F. Borghetti and Paolo Bobbio},
  journal={Journal of International Medical Research},
  year={1994},
  volume={22},
  pages={153 - 159}
}
The alteration of cytosolic free calcium concentration is an important event during cellular ischaemia. Calcium channel blockers have been shown to be beneficial during experimental ischaemic organ protection. To investigate the mechanisms of this protection, the behaviour of type II pneumocyte cultures, subjected to warm and cold metabolic ischaemia (6 h), was studied. The cells were incubated in electrolytic solutions and treated with high doses of verapamil (10 mg/l) or diltiazem (100 mg/l… 

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