The Effect of Tempol Administration on the Aortic Contractile Responses in Rat Preeclampsia Model

@inproceedings{Talebianpoor2012TheEO,
  title={The Effect of Tempol Administration on the Aortic Contractile Responses in Rat Preeclampsia Model},
  author={Mohammad Sharif Talebianpoor and Hossein Mirkhani},
  booktitle={ISRN pharmacology},
  year={2012}
}
It is reported that reactive oxygen species production has a critical role in the manifestations and complications of preeclampsia. In the present study, the effect of tempol on the response changes of aortic rings of preeclamptic rats has been studied. Preeclamptic rats (induced by L-NAME) were treated with three different oral doses of tempol (20, 60 and 180 mg/kg/day) from the Day 10 of gestation. Systolic blood pressure, plasma malondialdehyde and 8-isoprostane and the vascular effects of… CONTINUE READING

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