The Effect of Supraphysiologic Levels of Iodine on Patients with Cyclic Mastalgia

@article{Kessler2004TheEO,
  title={The Effect of Supraphysiologic Levels of Iodine on Patients with Cyclic Mastalgia},
  author={Jack Kessler},
  journal={The Breast Journal},
  year={2004},
  volume={10}
}
  • J. Kessler
  • Published 1 July 2004
  • Medicine
  • The Breast Journal
Abstract:  A randomized, double‐blind, placebo‐controlled, multicenter clinical trial was conducted with 111 otherwise healthy euthyroid women with a history of breast pain. Patients had to document moderate or severe breast pain by recording a score ≥5 on a visual analog scale (VAS) of pain for ≥6 days per cycle and had to present with fibrosis involving at least 25% of both breast surfaces. Subjects could not be effectively treated with more conservative measures such as local heat or… 
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The UIC values indicate that Iranian cancer patients were seriously iodine deficient according to WHO/UNIC EF/IC C IDD, and that this is a suitable index to assess iodine status in Iranians.
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References

SHOWING 1-10 OF 58 REFERENCES
Update on Clinical and Research Issues in Cyclical Mastalgia
TLDR
It is suggested that understanding and effective management of cyclical mastalgia will be fostered by a systematic biopsychosocial, interdisciplinary approach to research.
Iodine replacement in fibrocystic disease of the breast.
TLDR
The fibrocystic breast reacts differently to sodium iodide, protein-bound iodide and molecular iodine; molecular iodine is nonthyrotropic and was the most beneficial.
Cyclical mastalgia: prevalence and impact in an outpatient breast clinic sample.
TLDR
Reported prevalences of mastalgia obtained in this sample are higher than those reported in British studies; possible reasons for these differences are discussed.
Cyclical mastopathy and premenopausal breast cancer risk
TLDR
An association of cyclical breast tenderness with breast cancer risk in premenopausal women is identified and persists after consideration of diet and the effects of other Breast cancer risk factors.
NATURAL HISTORY OF BREAST PAIN
TLDR
The study indicates that the type of pain and age at onset may allow some prediction of the course of the disease and may aid the choice of therapy.
Prolactin response to thyrotropin-releasing hormone as a guideline for cyclical mastalgia treatment.
TLDR
The hypothesis that PRL response to TRH could be used to identify patients affected with cyclical mastalgia that are likely to benefit by bromocriptine treatment is confirmed.
Mastodynia due to fibrocystic disease of the breast controlled with thyroid hormone.
  • N. Estes
  • Medicine
    American journal of surgery
  • 1981
TLDR
Further trials of levothyroxine in patients with mastodynia due to fibrocystic disease appear justified, with rapid pain relief and normalization of prolactin levels after treatment.
Management of breast pain.
TLDR
Tamoxifen is the most effective and least toxic agent available for the treatment of severe chronic breast pain and must be tailored to individual patient requirement and symptom control balanced against troublesome side-effects.
PREDICTION OF RESPONSE TO ENDOCRINE THERAPY IN PRONOUNCED CYCLICAL MASTALGIA USING DYNAMIC TESTS OF PROLACTIN RELEASE
TLDR
It is indicated that dynamic tests of prolactin release in cyclical mastalgia may be useful in predicting the subsequent satisfactory response to endocrine therapy if a high peak prolactIn release is induced.
Increased hypothalamic dopaminergic tone only in early parous women with either malignant or benign breast tumors.
  • C. Ortega-González, A. Parra, +6 authors I. Coria
  • Medicine
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • 2002
TLDR
The results of this study suggest the existence of an increased hypothalamic dopaminergic tone in early parous women but not in late parous or nulliparous women with malignant or benign breast tumors in comparison with similar healthy women.
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