The Effect of Substance P on an Intervertebral Disc Rat Organ Culture Model.

@article{Koerner2016TheEO,
  title={The Effect of Substance P on an Intervertebral Disc Rat Organ Culture Model.},
  author={John D. Koerner and Dessislava Z. Markova and Gregory D. Schroeder and Jeffery A Rihn and Alan S. Hilibrand and Alexander R. Vaccaro and David Greg Anderson and Christopher K. Kepler},
  journal={Spine},
  year={2016},
  volume={41 24},
  pages={1851-1859}
}
STUDY DESIGN Laboratory study. OBJECTIVE Evaluate the effect of substance P (SP) on an intervertebral disc rat organ culture model. SUMMARY OF BACKGROUND DATA Monolayer cell experiments have demonstrated that exposure intervertebral disc tissue cells to SP leads to upregulation in inflammatory cytokine expression; however, this has not been evaluated in a more complex organ culture model. METHODS Forty-eight intervertebral discs from eight rats were used in an organ culture model… CONTINUE READING
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