The Effect of Social Experience on Serotonergic Modulation of the Escape Circuit of Crayfish

@article{Yeh1996TheEO,
  title={The Effect of Social Experience on Serotonergic Modulation of the Escape Circuit of Crayfish},
  author={S R Yeh and Russell A. Fricke and Donald H. Edwards},
  journal={Science},
  year={1996},
  volume={271},
  pages={366 - 369}
}
The neuromodulator serotonin has widespread effects in the nervous systems of many animals, often influencing aggression and dominance status. In crayfish, the effect of serotonin on the neural circuit for tailflip escape behavior was found to depend on the animal's social experience. Serotonin reversibly enhanced the response to sensory stimuli of the lateral giant (LG) tailflip command neuron in socially dominant crayfish, reversibly inhibited it in subordinate animals, and persistently… 
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Dopamine Modulates the Lateral Giant Neuron and Serotonergic Facilitation in Crayfish
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Dopamine has two distinct effects on serotonergic facilitation that depends on how long dopaminergic pathways have been activated, which are shown to be temporal differences in the interaction between the two modulatory effects.
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References

SHOWING 1-10 OF 33 REFERENCES
Serotonin and octopamine have opposite modulatory effects on the crayfish's lateral giant escape reaction
  • D. Glanzman, F. Krasne
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1983
TLDR
Although serotonin and octopamine modulate the excitability of the escape response, neither monoamine appears to significantly alter the rate at which this response habituates.
Multiple receptors mediate the modulatory effects of serotonergic neurons in a small neural network.
TLDR
The gastropyloric receptor cells are a set of cholinergic/serotonergic mechanosensory neurons that modulate the activity of neural networks in the crab stomatogastric ganglion (STG) and it is shown that these three classes of modulatory response in the STG neurons are mediated by distinct 5-HT receptor subtypes.
The mechanism of tonic inhibition of crayfish escape behavior: distal inhibition and its functional significance
  • E.C.L. Vu, SC Lee, FB Krasne
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1993
TLDR
It was shown that the relativity of distal inhibition arises from its interaction with the process of saturation of excitation and that tonic inhibition does indeed interact with excitatory saturation as predicted.
Excitation and habituation of the crayfish escape reflex: the depolarizing response in lateral giant fibres of the isolated abdomen.
  • F. Krasne
  • Biology
    The Journal of experimental biology
  • 1969
The tail-flip escape reflex of the crayfish shows marked habituation and is very amenable to detailed electrophysiological study. It thus provides a model system for comprehending the neural basis
Sub-types of serotonin receptors: biochemical changes and pharmacological consequences.
TLDR
The present review summarizes the evidence implicating the role of specific serotonin receptor sub-types in eating disorders, sleep, sexual activity, anxiety states, aggression, schizophrenia and depression.
Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA.
TLDR
Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine, and adults manifested a distinct behavioral syndrome, including enhanced aggression in males.
Crayfish escape behavior and central synapses. I. Neural circuit exciting lateral giant fiber.
  • R. Zucker
  • Biology
    Journal of neurophysiology
  • 1972
TLDR
Recent experiments by Wine and Krasne show that a phasic mechanical stimulus to the tail leads to tail flicks that are always mediatecl by lateral giant fiber activity, therefore, the lateral giant is a critical decision fiber for the behavior.
Impulsive aggression and central serotonergic system function in humans: an example of a dimensional brain‐behavior relationship
  • E. Coccaro
  • Psychology, Biology
    International clinical psychopharmacology
  • 1992
TLDR
The results of these studies suggest that reduced overall central 5‐HT function in the limbic‐hypothalamic system is associated with suicidal and/or impulsive aggressive behaviors in patients with major mood and/ or personality disorders and that diminished 5-HT post‐synaptic receptor function in this brain region may be an important biological correlate of these behaviors.
Postsynaptic modulation of rectifying electrical synaptic inputs to the LG escape command neuron in crayfish
TLDR
Electrophysiological techniques are used to show that the connections between three major mechanosensory interneurons and LG rectify, and that their inputs to LG can be reduced by post Synaptic depolarization and increased by postsynaptic hyperpolarization.
...
1
2
3
4
...