The Effect of Quinidine on Calcium Accumulation by Isolated Sarcoplasmic Reticulum of Skeletal and Cardiac Muscle

@article{Fuchs1968TheEO,
  title={The Effect of Quinidine on Calcium Accumulation by Isolated Sarcoplasmic Reticulum of Skeletal and Cardiac Muscle},
  author={Franklin Fuchs and Edward W. Gertz and Fred Briggs},
  journal={The Journal of General Physiology},
  year={1968},
  volume={52},
  pages={955 - 968}
}
Quinidine potentiates twitch tension and (at higher concentrations) causes contracture of skeletal muscle whereas the same drug reduces tension development of cardiac muscle. To gain insight into the possible differences in the excitation-contraction coupling mechanism of the two types of muscle the effect of quinidine on calcium accumulation by isolated sarcoplasmic reticulum from skeletal and cardiac muscle was investigated. In a medium containing ATP, Mg(++), oxalate, and (45)Ca… CONTINUE READING

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Intracellular mechanism of quinidine action on muscle contraction

Naunyn-Schmiedeberg's Archives of Pharmacology • 1984
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