The Effect of Preconception-Initiated Low-Dose Aspirin on Human Chorionic Gonadotropin–Detected Pregnancy, Pregnancy Loss, and Live Birth

@article{Naimi2021TheEO,
  title={The Effect of Preconception-Initiated Low-Dose Aspirin on Human Chorionic Gonadotropin–Detected Pregnancy, Pregnancy Loss, and Live Birth},
  author={Ashley I. Naimi and Neil Perkins and Lindsey A. Sjaarda and Sunni L. Mumford and Robert William Platt and Robert M Silver and Enrique F. Schisterman},
  journal={Annals of Internal Medicine},
  year={2021},
  volume={174},
  pages={595 - 601}
}
BACKGROUND A previous large randomized trial indicated that preconception-initiated low-dose aspirin (LDA) therapy did not have a positive effect on pregnancy outcomes. However, this trial was subject to nonadherence, which was not taken into account by the intention-to-treat approach. OBJECTIVE To estimate per protocol effects of preconception-initiated LDA on pregnancy loss and live birth. DESIGN The EAGeR (Effects of Aspirin on Gestation and Reproduction) trial was used to construct a… 

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