The Effect of PS Content on the Ability of Natural Membranes to Fuse with Positively Charged Liposomes and Lipoplexes

@article{Stebelska2005TheEO,
  title={The Effect of PS Content on the Ability of Natural Membranes to Fuse with Positively Charged Liposomes and Lipoplexes},
  author={Katarzyna Stebelska and Patrycja M. Dubielecka and Aleksander F. Sikorski},
  journal={The Journal of Membrane Biology},
  year={2005},
  volume={206},
  pages={203-214}
}
Supramolecular aggregates containing cationic lipids have been widely used as transfection mediators due to their ability to interact with negatively charged DNA molecules and biological membranes. First steps of the process leading to transfection are partly electrostatic, partly hydrophobic interactions of liposomes/lipoplexes with cell and/or endosomal membrane. Negatively charged compounds of biological membranes, namely glycolipids, glycoproteins and phosphatidylserine (PS), are… CONTINUE READING

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