The Effect of PPE-Induced Emphysema and Chronic LPS-Induced Pulmonary Inflammation on Atherosclerosis Development in APOE*3-LEIDEN Mice

@inproceedings{Khedoe2013TheEO,
  title={The Effect of PPE-Induced Emphysema and Chronic LPS-Induced Pulmonary Inflammation on Atherosclerosis Development in APOE*3-LEIDEN Mice},
  author={P. Padmini S. J. Khedoe and Man C. Wong and Gerry T. M. Wagenaar and Jaap J. Plomp and Miranda Van Eck and Louis M. Havekes and Patrick C. N. Rensen and Pieter S Hiemstra and Jimmy F. P. Berb{\'e}e},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary inflammation, airways obstruction and emphysema, and is a risk factor for cardiovascular disease (CVD). However, the contribution of these individual COPD components to this increased risk is unknown. Therefore, the aim of this study was to determine the contribution of emphysema in the presence or absence of pulmonary inflammation to the increased risk of CVD, using a mouse model for atherosclerosis. Because… CONTINUE READING
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