The Effect of Oxygen on Biochemical Networks and the Evolution of Complex Life

  title={The Effect of Oxygen on Biochemical Networks and the Evolution of Complex Life},
  author={Jason Raymond and Daniel Segr{\`e}},
  pages={1764 - 1767}
The evolution of oxygenic photosynthesis and ensuing oxygenation of Earth's atmosphere represent a major transition in the history of life. Although many organisms retreated to anoxic environments, others evolved to use oxygen as a high–potential redox couple while concomitantly mitigating its toxicity. To understand the changes in biochemistry and enzymology that accompanied adaptation to O2, we integrated network analysis with information on enzyme evolution to infer how oxygen availability… 

The Impact of Oxygen on Metabolic Evolution: A Chemoinformatic Investigation

A comprehensive comparative analysis of structures, chemical properties and chemical reactions of anaerobic and aerobic metabolites indicates that aerobic metabolism has expanded the structural and chemical space of metabolites considerably, including the appearance of 130 novel molecular scaffolds.

Aerobic metabolism underlies complexity and capacity

Arguments from thermodynamics, evolution, metabolic network analysis, clinical observations and animal models are provided that are in accord with the centrality of oxygen in biology.

On the origin of oxygenic photosynthesis and Cyanobacteria.

The evidence reviewed here highlights some of the most recent advances on the origin of photosynthesis both at the genomic and gene family level.

The evolution of oxygen-utilizing enzymes suggests early biosphere oxygenation.

Ph phylogenetic analysis of all known oxygen-utilizing and -producing enzymes (O2-enzymes) indicates that oxygen became widely available to living organisms well before the Great Oxidation Event, suggesting a wider availability of oxygen around 3.1 Ga.

How did life survive Earth's great oxygenation?

Oxygen in the evolution of complex life and the price we pay.

  • V. Thannickal
  • Biology
    American journal of respiratory cell and molecular biology
  • 2009
An understanding of the key role of O2 in the evolution of complex life and mammalian physiology may provide novel insights of O1, and its metabolites (reactive oxygen species), in the pathophysiology of diseases that affect the lung.

Evolution of oxygen utilization in multicellular organisms and implications for cell signalling in tissue engineering

Understanding the role of different levels of oxygen for normal cell function as well as control of complex signalling cascades is paramount to effectively build 3D tissues in vitro and their subsequent survival when implanted.

Evolution of photosynthesis.

An expanding wealth of genetic information, together with biochemical, biophysical, and physiological data, reveals a mosaic of photosynthetic features that provide an increasingly robust framework to formulate and evaluate hypotheses concerning the origin and evolution of photosynthesis.

CHAPTER 1 Redox Metabolism and Life

This chapter describes how, throughout the course of evolution, energy metabolism, which is based on redox reactions, has limited life and simultaneously exerted a strong selection pressure for



The origin of atmospheric oxygen on Earth: The innovation of oxygenic photosynthesis

A thermodynamic analysis is presented showing that bicarbonate (formed by dissolution of CO2) is a more efficient alternative substrate than water for O2 production by oxygenic phototrophs, and it is proposed that bricarbonate was the thermodynamically preferred reductant before water in the evolution of oxygenic photosynthesis.

The geological consequences of evolution

The example of oxygenic photosynthesis and the redox history of atmospheres and oceans illustrates the complex relationship between evolution and environmental change.

A cross species comparison of metabolic network functions.

A comparison between structural and functional similarities reveals that organisms with a similar structure do not necessarily show similar biological functions, indicating that this network function has been a target in the evolutionary past of the corresponding organisms.

Expanding Metabolic Networks: Scopes of Compounds, Robustness, and Evolution

The outcome of network expansion is in general very robust against elimination of single or few reactions and it is hypothesized that the expansion process displays characteristics of the evolution of metabolism such as the temporal order of the emergence of metabolic pathways.

The Interface Between the Biological and Inorganic Worlds: Iron-Sulfur Metalloclusters

Complex iron-sulfur metalloclusters form the active sites of the enzymes that catalyze redox transformations of N2, CO, and H2, which are likely components of Earth's primordial atmosphere. Although

When Did Photosynthesis Emerge on Earth?

Des Marais discusses recent geological and molecular biological evidence, such as the paper by Xiong et al., that photosynthesis emerged at least 2,800 million years ago.

Molecular evidence for the early evolution of photosynthesis.

Phylogenetic analyses of multiple magnesium-tetrapyrrole biosynthesis genes using a combination of distance, maximum parsimony, and maximum likelihood methods indicate that heliobacteria are closest to the last common ancestor of all oxygenic photosynthetic lineages and that green sulfur bacteria and green nonsulfur bacteria are each other's closest relatives.

Structural analysis of expanding metabolic networks.

It is shown that reactions and compounds strongly differ in the generation in which they are attached to the network allowing conclusions for the temporal order of the acquisition during network evolution.

Hierarchical Organization of Modularity in Metabolic Networks

It is shown that the metabolic networks of 43 distinct organisms are organized into many small, highly connected topologic modules that combine in a hierarchical manner into larger, less cohesive units, with their number and degree of clustering following a power law.