The Effect of Oral α-Galactosidase on Intestinal Gas Production and Gas-Related Symptoms

@article{DiStefano2006TheEO,
  title={The Effect of Oral $\alpha$-Galactosidase on Intestinal Gas Production and Gas-Related Symptoms},
  author={Michele Di Stefano and Emanuela Miceli and Samantha Gotti and Antonio Missanelli and Samanta Mazzocchi and Gino Roberto Corazza},
  journal={Digestive Diseases and Sciences},
  year={2006},
  volume={52},
  pages={78-83}
}
Bloating, abdominal distention, and flatulence represent very frequent complaints in functional disorders but their pathophysiology and treatment are largely unknown. Patients frequently associate these symptoms with excessive intestinal gas and the reduction of gas production may represent an effective strategy. The aim was to evaluate the effect of α-galactosidase administration, in a randomized double-blind placebo-controlled protocol, on intestinal gas production and gas-related symptoms… 

Does oral α-galactosidase relieve irritable bowel symptoms?

No evidence to support the use of AG routinely in IBS patients is found, and improvement of clinical response at 4-week follow-up may suggest a long-term effect of unknown mechanism, but could also be attributed to non-responder drop out.

Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment

Oral α-galactosidase taken with high G OS foods provides a clinically significant reduction in symptoms in GOS-sensitive individuals with IBS, and this strategy can be translated into practice to improve tolerance to high GOS foods as an adjunct therapy to the low FODMAP diet.

Efficacy and tolerability of α-galactosidase in treating gas-related symptoms in children: a randomized, double-blind, placebo controlled trial

Although larger and longer trials are needed to confirm this result, α-galactosidase seems to be a safe, well tolerated and effective treatment for gas-related symptoms in the pediatric population.

α-Galactosidase levels in irritable bowel syndrome subtypes and quality of life of patients

It is shown that IBS impairs QOL in patients, and it is suggested that future studies needed for the role of AG deficiency in IBS patients are suggested.

Fabry disease – a multisystemic disease with gastrointestinal manifestations

In addition to a timely initiation of FD-specific therapy, affected patients with GI symptoms might benefit from a FODMAP-low diet, pro- and prebiotics and/or low-cost oral substitution with AGAL to support digestion and reduce dysbiosis.

A pilot trial on subjects with lactose and/or oligosaccharides intolerance treated with a fixed mixture of pure and enteric-coated α- and β-galactosidase

Even with the uncontrolled diet, intolerant subjects treated with DDM Galactosidase exhibited reduced gut symptoms significantly better than the control treatment as well as having a diet devoid of offending foods.

Intra-Laboratory Validation of Alpha-Galactosidase Activity Measurement in Dietary Supplements

The proven method achieved good performance in the quantitative determination of α-Gal activity in commercial food supplements in accordance with the International Council for Harmonisation of Technical Requirements for Pharmaceuticals guidelines and is suitable as a rapid in-house quality control test.

Perceptions of flatulence from bean consumption among adults in 3 feeding studies

Investigating the perception of increased flatulence and gastrointestinal discomfort among participants who consumed a ½ cup of beans daily for 8 or 12 weeks found people's concerns about excessive flatulence from eating beans may be exaggerated.

Production of α- and β-galactosidases from Bifidobacterium longum subsp. longum RD47.

B. longum RD47 may be used for the production of α- and β-galactosidases, which may reduce the levels of flatulence factors, on the basis of the results obtained in this study.

References

SHOWING 1-10 OF 60 REFERENCES

Impaired transit and tolerance of intestinal gas in the irritable bowel syndrome

A large proportion of patients with IBS can be shown to have impaired transit and tolerance of intestinal gas loads, which may represent a possible mechanism of IBS symptoms, specifically pain and bloating.

Effect of Lactobacillus plantarum 299v on Colonic Fermentation and Symptoms of Irritable Bowel Syndrome

In conclusion, Lactobacillus plantarum 299V in this study did not appear to alter colonic fermentation or improve symptoms in patients with the irritable bowel syndrome.

Prokinetic effects in patients with intestinal gas retention.

In patients with intestinal gas retention, pharmacological stimulation of intestinal propulsion improves gas transit, abdominal symptoms, and distention.

Does Beano prevent gas? A double-blind crossover study of oral alpha-galactosidase to treat dietary oligosaccharide intolerance.

Oral alpha-galactosidase solution is efficacious, at least in some patients, for the prophylaxis of gastrointestinal intolerance of oligosaccharides.

Effect of simethicone on lactulose-induced H2 production and gastrointestinal symptoms.

There was no demonstrable effect of simethicone on symptoms or intestinal gas production caused by carbohydrate malabsorption in a randomized, double-blind cross-over study of healthy volunteers.

Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles.

B infantis 35624 alleviates symptoms in IBS; this symptomatic response was associated with normalization of the ratio of an anti-inflammatory to a proinflammatory cytokine, suggesting an immune-modulating role for this organism, in this disorder.

The Relation of Passage of Gas and Abdominal Bloating to Colonic Gas Production

The results show that symptoms commonly attributed to excess intestinal gas do not necessarily reflect increased gas production and the influence of the fiber preparations on breath hydrogen excretion in five participants.

Effects of beano on the tolerability and pharmacodynamics of acarbose.

Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome

The results of the study indicate that the administration of Lb.
...