• Corpus ID: 79344833

The Effect of Novel Anti-inflammatory Drugs on the Cyclooxygenase Enzymes and Recovery of Mucosal Barrier Function

@inproceedings{Marshall2010TheEO,
  title={The Effect of Novel Anti-inflammatory Drugs on the Cyclooxygenase Enzymes and Recovery of Mucosal Barrier Function},
  author={John F Marshall},
  year={2010}
}
MARSHALL, JOHN FRASER. The Effect of Novel Anti-inflammatory Drugs on the Cyclooxygenase Enzymes and Recovery of Mucosal Barrier Function. (Under the direction of Anthony T Blikslager). The non-steroidal anti-inflammatory drugs (NSAIDs) are a large group of drugs that are commonly used for the treatment of pain and inflammation in the veterinary species. The NSAIDs inhibit the action of the cyclooxygenase (COX) enzymes, COX-1 and COX-2, to reduce the production of prostaglandins. However, their… 
Biochemical and epidemiological investigations of non-steroidal anti-inflammatory drug usage and related side effects in equids
TLDR
Findings from experimental settings are confirmed that NSAIDs firocoxib is COX-2 selective and that flunixin meglumine and phenylbutazone are non-selective COX inhibitors and therefore their administration carries a greater risk of toxicity.

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